Document Detail


Effects of dilevalol on rest and supine exercise hemodynamics in mild to moderate systemic hypertension.
MedLine Citation:
PMID:  2563624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eight mildly to moderately hypertensive subjects free of any antihypertensive medications and on a normal salt diet performed maximal supine arm exercise. Before starting the exercise, a right-sided cardiac catheterization was performed to measure hemodynamic parameters before and during exercise. All patients had normal increases in cardiac output for the level of exercise performed and the peripheral vascular resistance diminished appropriately. An increase in the right atrial and pulmonary artery wedge pressures during exercise could be explained by increased venous return. After the baseline testing, rest and exercise hemodynamics were repeated 2 hours after the administration of 400 mg of dilevalol, a new beta blocker. For the next 2 weeks the patients received 400 mg of the study drug twice a day, with repeat studies obtained thereafter. As with other beta blockers, dilevalol decreases the heart rate and cardiac output on exercise, but, in addition, it induces a decrease in the resting systemic vascular resistance. This action is similar to its isomer, labetalol.
Authors:
W J Bugni; C W Ayers; R Ashby; P A Bittle; G Ramirez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  63     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-17     Completed Date:  1989-03-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  452-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Internal Medicine, James A. Haley Veterans Administration Hospital, Tampa, Florida 33612.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology*
Adult
Blood Pressure / drug effects
Carbon Dioxide / physiology
Heart Catheterization
Heart Rate / drug effects
Hemodynamics / drug effects*
Humans
Hypertension / physiopathology*
Labetalol / pharmacology*
Male
Middle Aged
Oxygen Consumption
Physical Exertion*
Supination
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 124-38-9/Carbon Dioxide; 36894-69-6/Labetalol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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