Document Detail


Effects of dihydroxy bile acids and hydroxy fatty acids on the absorption of oleic acid in the human jejunum.
MedLine Citation:
PMID:  338629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perfusion studies of the normal human jejunum were performed to test whether dihydroxy bile acids and hydroxy fatty acids inhibit the absorption of oleic acid, since previous reports documented their inhibitory effects on the absorption of several other organic solutes. 3 mM deoxycholate and 7 mM glycodeoxycholate inhibited the absorption of 3 mM oleic acid in isotonic micellar solutions while inducing net fluid secretion. Similarly, fractional absorption of oleic acid decreased in the presence of hydroxy fatty acids. However, only the changes induced by 2 mM ricinoleic acid could be distinguished from changes induced by an increase in total fatty acid concentration. Under all experimental conditions, close linear relationships existed between net water movement and fractional absorption of glucose, xylose, and fatty acids, as well as between the absorption rates of these solutes. In contrast, net fluid secretion induced by hypertonic D-mannitol (450 mosmol/liter) had no effect on solute absorption. Our data and observations in the literature do not allow formulation of a hypothesis which would adequately define all effects of dihydroxy bile acids and fatty acids on intestinal transport processes. The observations help explain the malabsorption of fat and other nutrients in patients with the blind loop syndrome.
Authors:
R Wanitschke; H V Ammon
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  61     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1978 Jan 
Date Detail:
Created Date:  1978-02-23     Completed Date:  1978-02-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  178-86     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Transport, Active
Blind Loop Syndrome / complications
Celiac Disease / etiology
Clinical Trials as Topic
Deoxycholic Acid / pharmacology*
Glucose / metabolism
Humans
Intestinal Absorption / drug effects*
Jejunum / metabolism
Male
Oleic Acids / metabolism*
Ricinoleic Acids / pharmacology
Stearic Acids / pharmacology*
Water / metabolism
Xylose / metabolism
Chemical
Reg. No./Substance:
0/Oleic Acids; 0/Ricinoleic Acids; 0/Stearic Acids; 0/Xylose; 50-99-7/Glucose; 7732-18-5/Water; 83-44-3/Deoxycholic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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