Document Detail


Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes.
MedLine Citation:
PMID:  18801408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSIONS: DHT inhibits adipogenic differentiation of hMSCs and human preadipocytes through an AR-mediated pathway, but it does not affect the proliferation of either hMSCs or preadipocytes. Androgen effects on fat mass represent the combined effect of decreased differentiation of fat cell precursors, increased lipolysis, and reduced lipid accumulation.
Authors:
Vandana Gupta; Shalender Bhasin; Wen Guo; Rajan Singh; Rika Miki; Pratibha Chauhan; Karen Choong; Tamara Tchkonia; Nathan K Lebrasseur; John N Flanagan; James A Hamilton; Jason C Viereck; Navjot S Narula; James L Kirkland; Ravi Jasuja
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-08-28
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  296     ISSN:  0303-7207     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-02-20     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  32-40     Citation Subset:  IM    
Affiliation:
Department of Medicine, Boston University, School of Medicine, Boston Medical Center, Boston, MA 02118, USA.
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MeSH Terms
Descriptor/Qualifier:
Adipocytes / drug effects*,  physiology
Adipogenesis / drug effects
Adult
Animals
Cell Differentiation / drug effects*
Cell Proliferation / drug effects*
Cells, Cultured
Dihydrotestosterone / pharmacology*
Epididymis
Humans
Lipolysis / drug effects
Male
Mesenchymal Stromal Cells / drug effects*,  physiology
Mice
Mice, Inbred C57BL
Middle Aged
Orchiectomy
Receptors, Androgen / physiology
Signal Transduction / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
AG14369/AG/NIA NIH HHS; DK49296/DK/NIDDK NIH HHS; DK56891/DK/NIDDK NIH HHS; DK59261/DK/NIDDK NIH HHS; DK70534/DK/NIDDK NIH HHS; P50 HL083801-040003/HL/NHLBI NIH HHS; U54HD41748/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Androgen; 521-18-6/Dihydrotestosterone
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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