Document Detail


Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats.
MedLine Citation:
PMID:  11743226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of hypertension and of treatment with dihydropyridine-type Ca2+ antagonists and the vasodilator hydralazine on renal arterial tree were investigated in spontaneously hypertensive rats (SHR) with quantitative microanatomical techniques. Pharmacological treatment decreased to a similar extent systolic blood pressure values in SHR. Increased thickness of the tunica media of intrarenal arteries accompanied and luminal narrowing were observed in control SHR. Lercanidipine, manidipine, and nicardipine significantly countered wall thickening and luminal narrowing. Hydralazine countered luminal narrowing only. Dihydropyridines exerted renal vasocilatory activity primarily on resistance arteries, being lercanidipine the only compound active on small sized arteries.
Authors:
Maurizio Sabbatini; Amedeo Leonardi; Rodolfo Testa; Daniele Tomassoni; Lucia Vitaioli; Francesco Amenta
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  39     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-14     Completed Date:  2002-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-48     Citation Subset:  IM    
Affiliation:
Sezione di Anatomia Umana, Dipartimento di Scienze Farmacologiche e Medicina, Università of Camerino, 62032 Camerino, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Calcium Channel Blockers / pharmacology*
Dihydropyridines / pharmacology*
Hydralazine / pharmacology
Kidney / blood supply
Male
Nicardipine / pharmacology
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Renal Artery / drug effects*,  pathology
Tunica Media / pathology
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Dihydropyridines; 0/Vasodilator Agents; 100427-26-7/lercanidipine; 55985-32-5/Nicardipine; 86-54-4/Hydralazine; 89226-50-6/manidipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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