| Effects of digoxin-specific antibody Fab fragment (Digibind) on blood pressure and renal water-sodium metabolism in 5/6 reduced renal mass hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 10371371 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The importance of increased endogenous digitalis-like factor (EDLF) in volume-expanded hypertension has been generally agreed. To further clarify the role of EDLF on the development of hypertension and renal water-sodium handling in 5/6 reduced renal mass hypertensive rats (RRM), we studied the effects of acute administration of digoxin-specific antibody Fab fragment (Digibind) in the early phase and the chronic phase of hypertension in RRM. RRM and sham-operated rats were given 1% saline for 1 or 4 weeks. RRM were injected Digibind (60 mg/kg) or vehicle (0.9% saline) intravenously in the first or fourth week under thiobutabarbital anesthesia. All sham-operated rats were administered Digibind under the same condition. Digibind altered neither blood pressure, heart rate, urine volume, nor urinary sodium excretion in sham-operated rats. However, Digibind produced a gradual but significant decline in mean arterial pressure to the level slightly above that in sham-operated rats from 153 +/- 5 to 131 +/- 5 mm Hg in the first week and from 181 +/- 6 to 129 +/- 4 mm Hg in the fourth week without any significant change in heart rate. The decrease in mean arterial pressure at 160 min after Digibind administration in the fourth week (-48 +/- 5 mm Hg) was greater than that in the first week (-22 +/- 4 mm Hg). No differences were observed in urine volume, urinary sodium excretion, or plasma norepinephrine concentration between Digibind and vehicle-treated RRM in either week. These data suggest that EDLF would contribute to both the early and chronic phase in the development of hypertension in RRM. |
| | |
Authors:
|
J Kaide; N Ura; T Torii; M Nakagawa; T Takada; K Shimamoto |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of hypertension Volume: 12 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1999 Jun |
Date Detail:
|
Created Date: 1999-08-02 Completed Date: 1999-08-02 Revised Date: 2009-02-24 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 611-9 Citation Subset: IM |
Affiliation:
|
Second Department of Internal Medicine, Sapporo Medical University, School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects* Body Water / metabolism Cardenolides Digoxin / immunology* Heart Rate / drug effects Hypertension, Renal / metabolism* Immunoglobulin Fab Fragments / administration & dosage, pharmacology* Injections, Intravenous Kidney / drug effects, metabolism*, physiology Male Norepinephrine / blood Rats Rats, Sprague-Dawley Renal Circulation / drug effects Saponins / metabolism* Sodium / urine* |
| Chemical | |
Reg. No./Substance:
|
0/Cardenolides; 0/Immunoglobulin Fab Fragments; 0/Saponins; 0/digoxin antibodies Fab fragments; 0/digoxin-like factors; 20830-75-5/Digoxin; 51-41-2/Norepinephrine; 7440-23-5/Sodium |
| Comments/Corrections | |
Comment In:
|
Am J Hypertens. 2000 May;13(5 Pt 1):569-70
[PMID:
10826414
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic susceptibility of the donor kidney contributes to the development of renal damage after syng...
Next Document: Effects on regional renal blood flow when unclipping a two-kidney, one-clip hypertensive Wistar rat ...