Document Detail

Effects of digoxin on regional diaphragm function after thoracotomy in awake sheep.
MedLine Citation:
PMID:  8059071     Owner:  NLM     Status:  MEDLINE    
The effects of digoxin on diaphragmatic contraction were studied in 12 sheep, within 6 days after a right thoracotomy, during the period of intense diaphragmatic inhibition. Diaphragmatic function was assessed by implanting sonomicrometry crystals and electromyographic (EMG) electrodes in both the costal and crural diaphragmatic regions. Awake sheep were studied before and after intravenous digoxin (0.04 mg/kg) during both quiet breathing (QB) and during CO2 rebreathing, until the fractional concentration of expired CO2 (FETCO2) reached 0.10. After digoxin infusion, during both QB and at FETCO2 of 0.10, esophageal and transdiaphragmatic pressures increased (P < 0.05). After digoxin infusion no changes were measured for end-expiratory resting length, shortening fraction, shortening velocity or EMG activity of either diaphragmatic segment or for respiratory frequency, ventilation, tidal volume and FETCO2. We conclude that intravenous digoxin given to awake sheep after a thoracotomy increases Pdi, but does not alter diaphragmatic shortening nor alter the level of diaphragmatic activation either during QB or at FETCO2 of 0.10.
M D Fratacci; W R Kimball; J C Wain; E M Greene; W M Zapol
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration physiology     Volume:  95     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-09-15     Completed Date:  1994-09-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  259-71     Citation Subset:  IM    
Department of Anaesthesia, Harvard Medical School, Massachusetts General Hospital, Boston 02114.
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MeSH Terms
Carbon Dioxide / metabolism
Diaphragm / drug effects*
Digoxin / blood,  pharmacology*
Electric Stimulation
Electromyography / drug effects
Esophagus / physiology
Heart Rate / drug effects
Muscle Contraction / drug effects
Phrenic Nerve / physiology
Respiration, Artificial
Respiratory Mechanics / drug effects
Stomach / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide; 20830-75-5/Digoxin

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