Document Detail

Effects of digoxin on chemoreflex in patients with chronic heart failure.
MedLine Citation:
PMID:  11355009     Owner:  NLM     Status:  MEDLINE    
The effects of digitalis on the baroreflexes in human chronic heart failure have been well studied. Similarly, since it has been recently shown that chemoregulation remains generally effective during cardiac failure, the goal of this study was to evaluate the effects of a chronic administration of digoxin on the chemoreflexes. Hemodynamic and blood gas parameters were assessed in 7 patients with chronic congestive heart failure before and after chronic administration for 10 days of digoxin therapy (0.25 mg daily). In both situations measurements were performed 1/ in baseline conditions at room air and, 2/ after inhalation of pure O2 for 30 min, in order to inhibit the activation of the chemoreflexes. At room air, acute O2 inhalation resulted in a significant decrease in heart rate and cardiac output. After digoxin therapy, comparatively to pre-treatment values, cardiac output, stroke volume and PaO2 were significantly higher while heart rate, systemic resistance and pulmonary wedge pressure were lower. Furthermore, acute O2 inhalation did not modify heart rate or any hemodynamic variables. These results suggest that after digoxin therapy chemoreflex was no more activated in these patients. This effect may be related to the sympatho-inhibitory and to the positive inotropic effects of digoxin: improving hemodynamic and blood gas parameters may result in the inactivation of the reflex.
F Paganel; J M Maixent; R Gélisse; P Barnay; F Dodero; F Francheschi; S Lévy; A Saadjian
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cellular and molecular biology (Noisy-le-Grand, France)     Volume:  47     ISSN:  0145-5680     ISO Abbreviation:  Cell. Mol. Biol. (Noisy-le-grand)     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-05-16     Completed Date:  2001-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9216789     Medline TA:  Cell Mol Biol (Noisy-le-grand)     Country:  France    
Other Details:
Languages:  eng     Pagination:  335-40     Citation Subset:  IM    
Service de Cardiologie, H pital Nord Marseille, CHU Nord, Chemin des Bourrelly, Marseille, France.
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MeSH Terms
Blood Gas Analysis
Cardiac Output, Low / blood,  drug therapy*,  physiopathology
Cardiotonic Agents / pharmacology,  therapeutic use
Chemoreceptor Cells / metabolism*
Digoxin / pharmacology,  therapeutic use*
Hemodynamics / drug effects
Middle Aged
Oxygen / administration & dosage,  metabolism
Reflex / physiology*
Reg. No./Substance:
0/Cardiotonic Agents; 20830-75-5/Digoxin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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