| Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation--a randomized controlled trial. | |
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MedLine Citation:
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PMID: 15168036 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Evidence from in vitro studies suggests that antioxidant olive oil phenolic compounds can prevent LDL oxidation. However, in vivo evidence in support of this hypothesis is sparse. AIM OF THE STUDY: to establish the antioxidant effect of olive oils with differences in their phenolic compounds content in humans METHODS: A controlled, double blind, cross-over, randomized, clinical trial using three similar olive oils with increasing phenolic concentration (from 0 to 150 mg/Kg) was conducted in 30 healthy volunteers. Olive oils were administered over three periods of 3 weeks preceded by two-week washout periods. RESULTS: Urinary tyrosol and hydroxytyrosol increased (p < 0.020), in vivo plasma oxidized LDL decreased (p = 0.006), and ex vivo resistance of LDL to oxidation increased (p = 0.012) with the phenolic content of the olive oil administered. After virgin olive oil administration, an increase (p = 0.029) was observed in HDL cholesterol levels. CONCLUSIONS: Sustained consumption of virgin olive oil with the high phenolic content was more effective in protecting LDL from oxidation and in rising HDL cholesterol levels than that of other type of olive oils. Dose-dependent changes in oxidative stress markers, and phenolic compounds in urine, were observed with the phenolic content of the olive oil administered. Our results support the hypothesis that virgin olive oil consumption could provide benefits in the prevention of oxidative processes. |
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Authors:
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Jaume Marrugat; María-Isabel Covas; Montserrat Fitó; Helmut Schröder; Elisabet Miró-Casas; Eva Gimeno; M Carmen López-Sabater; Rafael de la Torre; Magí Farré; |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2004-01-06 |
Journal Detail:
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Title: European journal of nutrition Volume: 43 ISSN: 1436-6207 ISO Abbreviation: Eur J Nutr Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-28 Completed Date: 2004-10-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100888704 Medline TA: Eur J Nutr Country: Germany |
Other Details:
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Languages: eng Pagination: 140-7 Citation Subset: IM |
Affiliation:
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Lipids and Cardiovascular Epidemiology, Research Unit, Institut Municipal d'Investigació Mèdica, Carrer Dr Aiguader 80, 08003 Barcelona, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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metabolism* Cholesterol, HDL / blood Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Humans Lipoproteins, LDL / chemistry*, metabolism* Male Middle Aged Oxidation-Reduction Phenols / pharmacology* Phenylethyl Alcohol / analogs & derivatives*, urine Plant Oils / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Cholesterol, HDL; 0/Lipoproteins, LDL; 0/Phenols; 0/Plant Oils; 10597-60-1/3,4-dihydroxyphenylethanol; 501-94-0/4-hydroxyphenylethanol; 60-12-8/Phenylethyl Alcohol; 8001-25-0/olive oil |
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