| Effects of different ventilation strategies on lung injury in newborn rabbits. | |
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MedLine Citation:
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PMID: 22451169 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The results from experimental and clinical studies have shown that mechanical ventilation (MV) and/or hyperoxia may aggravate a pre-existing lung injury, or even cause lung injury in healthy lungs, despite the fact that it might be the only life-saving intervention available to a patient. The present study was designed to investigate the roles of MV and hyperoxia in the pathogenesis of lung injury. METHODS: Newborn New Zealand white rabbits were randomly assigned to an unventilated air control group or to one of the 2 × 3 × 3 ventilation strategies using a factorial design. The experimental groups were assigned different fractions of inspired oxygen (FiO(2) ), peak inspiratory pressures (PIP), and respiratory times (RT). The lung wet-to-dry ratio (W/D), lung histopathology scores, and cells in the bronchoalveolar lavage fluid (BALF) were analyzed for each group. The apoptosis levels were studied by immunohistochemistry and a terminal deoxynucleotidyl transferase dUTP nick end-labeling (TUNEL) assay. RESULTS: Different ventilation regimes induced alterations in microvascular permeability, differential histopathological grading, WBC and/or neutrophil and/or lymphocyte influx, and apoptosis levels; moreover, there were significant correlations and interaction effects between these indices. CONCLUSIONS: Our data demonstrate that different ventilation regimes can induce lung injury and that the interaction effects of the FiO(2) , the PIP and the RT may play crucial roles in the pathogenesis of lung injury. Pediatr Pulmonol. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Shaodong Hua; Xiaoying Zhang; Sheng Zhang; Jing Xu; Zhichun Feng |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-26 |
Journal Detail:
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Title: Pediatric pulmonology Volume: - ISSN: 1099-0496 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510590 Medline TA: Pediatr Pulmonol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Department of Pediatrics, BaYi Children's Hospital of The General Military Hospital of Beijing PLA, Beijing, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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