| Effects of different sweet preloads on incretin hormone secretion, gastric emptying, and postprandial glycemia in healthy humans. | |
| | |
MedLine Citation:
|
PMID: 22158727 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: Macronutrient "preloads" can stimulate glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), slow gastric emptying, and reduce postprandial glycemic excursions. After sweet preloads, these effects may be signaled by sodium-glucose cotransporter-1 (SGLT1), sweet taste receptors, or both. OBJECTIVE: We determined the effects of 4 sweet preloads on GIP and GLP-1 release, gastric emptying, and postprandial glycemia. DESIGN: Ten healthy subjects were studied on 4 separate occasions each. A preload drink containing 40 g glucose, 40 g tagatose/isomalt mixture (TIM), 40 g 3-O-methylglucose (3OMG; a nonmetabolized substrate of SGLT1), or 60 mg sucralose was consumed 15 min before a (13)C-octanoic acid-labeled mashed potato meal. Blood glucose, plasma total GLP-1 and GIP, serum insulin, and gastric emptying were determined. RESULTS: Both glucose and 3OMG stimulated GLP-1 and GIP release in advance of the meal (each P < 0.05), whereas TIM and sucralose did not. The overall postprandial GLP-1 response was greater after glucose, 3OMG, and TIM than after sucralose (P < 0.05), albeit later after TIM than the other preloads. The blood glucose and insulin responses in the first 30 min after the meal were greatest after glucose (each P < 0.05). Gastric emptying was slower after both 3OMG and TIM than after sucralose (each P < 0.05). CONCLUSIONS: In healthy humans, SGLT1 substrates stimulate GLP-1 and GIP and slow gastric emptying, regardless of whether they are metabolized, whereas the artificial sweetener sucralose does not. Poorly absorbed sweet tastants (TIM), which probably expose a greater length of gut to nutrients, result in delayed GLP-1 secretion but not in delayed GIP release. These observations have the potential to optimize the use of preloads for glycemic control. This trial was registered at www.actr.org.au as ACTRN12611000775910. |
| | |
Authors:
|
Tongzhi Wu; Beiyi R Zhao; Michelle J Bound; Helen L Checklin; Max Bellon; Tanya J Little; Richard L Young; Karen L Jones; Michael Horowitz; Christopher K Rayner |
Related Documents
:
|
15574137 - Diabetes-induced expression of activating transcription factor 3 in mouse primary senso... 1548387 - Reinforcement of poly(methyl methacrylate) with ultra-high-modulus polyethylene fibre. 9657347 - Improved fluorometric enzymatic sorbitol assay in human blood. 3666317 - Altered protein phosphorylation in sciatic nerve from rats with streptozocin-induced di... 8106637 - Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance... 16423547 - Involvement of norepinephrine in the hyperglycemic responses of the freshwater giant pr... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-7 |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: - ISSN: 1938-3207 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia and the Nerve Gut Laboratory, Royal Adelaide Hospital, Adelaide, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quantitative data on the magnitude of the systemic inflammatory response and its effect on micronutr...
Next Document: Increasing food acceptance in the home setting: a randomized controlled trial of parent-administered...