Document Detail

Effects of different once-a-day medications on 24-hour blood pressure recordings in hypertensives.
MedLine Citation:
PMID:  1799929     Owner:  NLM     Status:  MEDLINE    
Compliance with antihypertensive treatment can be increased by using medications that are taken only once daily. There is, however, concern as to whether the efficacy of such drugs is sufficient to cover 24 h. Ambulatory blood pressure monitoring (ABPM) is an ideal technique to assess the effect of this kind of drug and to determine over- or undertreatment. In this study three drugs were examined as once-a-day preparations. Thirty-six patients were treated with three different doses of bisoprolol, as an example of the beta 1-selective beta-blockers; 12 patients were treated with a combination of the AChE-inhibitor enalapril and hydrochlorothiazide; eight patients were treated with nifedipine once per day, a new galenic form of nifedipine, as an example of the calcium-channel blockers. In each group we saw a significant downward shift over the entire 24-h curve. Our results also show that using 24-h blood pressure monitoring devices can help establish an appropriate dose, avoid over- and undertreatment, and control the total burden of the patient.
B Höfling; K von Hoyningen-Huene
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Chronobiology international     Volume:  8     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  1991  
Date Detail:
Created Date:  1992-04-22     Completed Date:  1992-04-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  477-84     Citation Subset:  IM    
Medizinische Klinik I, Universität München, Germany.
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MeSH Terms
Antihypertensive Agents / administration & dosage*
Blood Pressure / drug effects
Blood Pressure Monitors
Circadian Rhythm / physiology*
Double-Blind Method
Drug Administration Schedule
Heart Rate / drug effects
Hypertension / drug therapy*,  physiopathology
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Antihypertensive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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