| Effects of different levels of cigarette smoke exposure on prognostic heart rate and rate--pressure-product parameters. | |
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MedLine Citation:
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PMID: 18628485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Reduced cigarette smoke exposure in adult smokers switching from a conventional cigarette (CC) to a potential exposure-reduced electrically heated cigarette smoking system (EHCSS) and no smoking (NS) improved exercise performance. The effects of reduced smoke exposure on the prognostic parameters heart rate (HR) and rate-pressure-product (RPP) were investigated. A total of 18 male adult CC-smokers were randomized in a 3-period cross-over study to CC, EHCSS, or to NS for 3 days each before performing spiroergometry. Exposure parameters declined from CC to EHCSS and to NS. Resting HR and RPP increased from NS to EHCSS and to CC. Chronotropic response/HR recovery were more pronounced in NS than in EHCSS and CC. RPPmax was similar in NS and EHCSS and lowest during CC. Reduced tobacco smoke exposure for 3 days improved the prognostic parameters HR and RPP in an apparently dose-dependent manner. |
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Authors:
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Martin Unverdorben; Anina van der Bijl; Linda Potgieter; Cornea Venter; Sagar Munjal; Qiwei Liang; Bernhardt Meyer; Hans-Jürgen Röthig |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-07-15 |
Journal Detail:
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Title: Journal of cardiovascular pharmacology and therapeutics Volume: 13 ISSN: 1074-2484 ISO Abbreviation: J. Cardiovasc. Pharmacol. Ther. Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-01 Completed Date: 2008-12-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602617 Medline TA: J Cardiovasc Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 175-82 Citation Subset: IM |
Affiliation:
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Research, Development & Engineering, Clinical Evaluation, Philip Morris USA, Richmond, Virginia, martin.unverdorben@pmusa.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects* Cross-Over Studies Dose-Response Relationship, Drug Exercise Test Heart Rate / drug effects* Humans Male Middle Aged Prognosis Single-Blind Method Smoking / adverse effects*, physiopathology Smoking Cessation* Spirometry Time Factors Tobacco Smoke Pollution / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Tobacco Smoke Pollution |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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