| Effects of different extremely low-frequency electromagnetic fields on osteoblasts. | |
| | |
MedLine Citation:
|
PMID: 17886004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is well known that the extremely low-frequency electromagnetic field (EMF) can promote the healing of bone fractures, but its mechanism remains poorly understood. The purpose of this study was to examine the response of neonatal rat calvarial bone cells to the rectangular electromagnetic field (REMF), triangular electromagnetic field (TEMF), sinusoidal electromagnetic field (SEMF), and pulsed electromagnetic field (PEMF). The stimulatory effects of EMF were evaluated by the proliferation (methyltetrazolium colorimetric assay), differentiation (alkaline phosphatase (ALP) activity), and mineralization (area of mineralized nodules of the cells). REMF treatment of osteoblasts increased cellular proliferation and decreased ALP activity (p < 0.05). TEMF had an accelerative effect on the cellular mineralized nodules (p < 0.05). SEMF treatment of osteoblasts decreased the cellular proliferation, increased ALP activity, and suppressed mineralized nodules formation (p < 0.05). PEMF promoted the proliferation of osteoblasts, inhibited their differentiation, and increased the mineralized nodules formation (p < 0.05). Moreover, the effects of PEMF on osteoblasts were concerned with the extracellular calcium, P2 receptor on the membrane, and PLC pathway, but the response of osteoblasts on SEMF was only related to PLC pathway. The results suggested that the waveforms of EMF were the crucial parameters to induce the response of osteoblasts. |
| | |
Authors:
|
Xiaojun Zhang; Jianbao Zhang; Xuemin Qu; Jun Wen |
Related Documents
:
|
18543014 - Effects of vitamin k(2) and risedronate on bone formation and resorption, osteocyte lac... 21659744 - Roger c. bone, md and the evolving paradigms of sepsis. 15215564 - Effects of nadroparin on bone histomorphometric parameters in rats. 12478364 - Static and dynamic osteogenesis: two different types of bone formation. 11264794 - Quantification of bone microarchitecture with the structure model index. 1613094 - Deformity and function in supracondylar fractures of the humerus in children variously ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Electromagnetic biology and medicine Volume: 26 ISSN: 1536-8378 ISO Abbreviation: Electromagn Biol Med Publication Date: 2007 |
Date Detail:
|
Created Date: 2007-09-21 Completed Date: 2007-11-26 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101133002 Medline TA: Electromagn Biol Med Country: United States |
Other Details:
|
Languages: eng Pagination: 167-77 Citation Subset: IM |
Affiliation:
|
Department of Physics, Fourth Military Medical University, Shanxi, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Animals, Newborn Calcification, Physiologic / physiology, radiation effects Cell Differentiation / radiation effects Cell Proliferation / radiation effects Cell Survival / radiation effects Cells, Cultured Dose-Response Relationship, Radiation Electricity Electromagnetic Fields Osteoblasts / cytology*, physiology*, radiation effects Radiation Dosage Rats Rats, Sprague-Dawley |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cytokine release from osteoblasts in response to different intensities of pulsed electromagnetic fie...
Next Document: Effects of weak, low-frequency pulsed electromagnetic fields (BEMER type) on gene expression of huma...