| Effects of different doses of free alpha-linolenic acid infused to the duodenum on the immune function of lactating dairy cows. | |
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MedLine Citation:
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PMID: 21214022 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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This study investigated the effect of a duodenal infusion of a C18:3 free fatty acid on the immune function of lactating dairy cows. Four primiparous Chinese Holstein cows fitted with duodenal cannulas received 0, 100, 200, 300, and 400 g/d of alpha-linolenic acid (LNA) in a two-treatment crossover design. Blood was collected and serum IgA, IgG, IgM, prostaglandin E2 (PGE2) and Th1/Th2 cytokines were determined. Results showed that increasing the supply of LNA to the small intestine of dairy cows linearly increased serum IgG and quadratically enhanced interferon-gamma (p < 0.05), whereas the concentrations of PGE2 declined linearly (p < 0.05) and those of interleukin (IL)-4 tended to decrease (p = 0.08). No difference was observed in serum IgA, IgM or other cytokines, such as IL-2, IL-6 and IL-10. This study demonstrated that in dairy cows, a post-ruminal infusion of high doses of LNA has immunomodulatory effects, possibly associated with a predisposition to a Th1-type response. |
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Authors:
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Peng Sun; Jiaqi Wang; Guang Yang; Khas-Erdene; Qingsheng Liu |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of animal nutrition Volume: 64 ISSN: 1745-039X ISO Abbreviation: Arch Anim Nutr Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-01-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101222433 Medline TA: Arch Anim Nutr Country: England |
Other Details:
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Languages: eng Pagination: 504-13 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Haidian District, Beijing, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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