Document Detail

Effects of different dialysis modalities on cardiac autonomic dysfunctions in end-stage renal disease patients: one year prospective study.
MedLine Citation:
PMID:  15083919     Owner:  NLM     Status:  MEDLINE    
Cardiac autonomic dysfunction (CAD) is a common problem in patients with end-stage renal disease (ESRD) and may contribute to the risk of cardiac mortality. Long-term effects of dialysis modalities on CAD in ESRD patients are not clear. In this one-year prospective study, we studied the effects of different dialysis modalities on CAD in ESRD patients. The study consisted of 20 ESRD patients who had the indications for initiating dialysis therapy (13 hemodialysis and 7 CAPD patients) and 15 healthy controls (M/F: 5/10; age 30 +/- 4). In all the subjects, first at the beginning of study (in patient groups just before initiating dialysis therapy) and then after 12 months, we studied 24 hours ECG-Holter monitoring and heart rate variability parameters (time and frequency domain analysis parameters; SDNN: standard deviations of nn intervals, rMSSD: square root of the median of standard deviation, HRVI: heart rate variability index, LF/HF: low frequency/high frequency). In ESRD patients, before dialysis therapy, all the parameters of time domain analysis were significantly lower compared to control group (p = 0.001). In patient groups, after dialysis therapy (on the 12th month), significant improvement was observed in time domain analysis parameters (p = 0.001). When dialysis modalities were compared, the increase in the time domain analysis parameters was significantly greater in the CAPD group compared to hemodialysis (HD) group. Our findings suggest that CAD is frequent in ESRD patients, a dialysis therapy of 12 months can cause significant improvement on CAD and the ameliorative effect of CAPD is better than HD.
Belda Dursun; Fatih Demircioglu; Halil Ibrahim Varan; Ibrahim Basarici; Mehmet Kabukcu; Fevzi Ersoy; Filiz Ersel; Gultekin Suleymanlar
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  26     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-04-15     Completed Date:  2004-08-03     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  35-8     Citation Subset:  IM    
Department of Internal Medicine, Division of Nephrology, School of Medicine, Akdeniz University, Antalya, Turkey.
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MeSH Terms
Electrocardiography, Ambulatory
Follow-Up Studies
Heart Conduction System / physiopathology*
Heart Rate / physiology
Kidney Failure, Chronic / physiopathology*,  therapy
Parasympathetic Nervous System / physiopathology*
Prospective Studies
Renal Dialysis / methods*
Sympathetic Nervous System / physiopathology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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