Document Detail

Effects of different catecholamines on the dynamics of volume expansion of crystalloid infusion.
MedLine Citation:
PMID:  15505449     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The authors studied the influence of alpha, beta, and dopaminergic catecholamines on blood volume expansion in conscious normovolemic sheep before, during, and after a bolus infusion of a crystalloid. METHODS: A 0.9% NaCl bolus (24 ml/kg in 20 min) was infused in four paired experiments each: no drug, dopamine infusion (50 microg . kg . min), isoproterenol infusion (0.1 microg . kg . min), and phenylephrine infusion (3 microg . kg . min). Blood volume expansion was calculated by the dilution of blood hemoglobin concentration. RESULTS: Dopamine had little effect on peak blood volume expansion (12.7 +/- 0.9 ml/kg) compared with 0.9% NaCl (13.0 +/- 2.7 ml/kg); in contrast, isoproterenol augmented blood volume expansion (18.5 +/- 1.8 ml/kg), and phenylephrine reduced blood volume expansion (8.9 +/- 1.4 ml/kg). Two hours after the 0.9% NaCl bolus, sustained blood volume expansion was greatest in the isoproterenol protocol (12.2 ml/kg), whereas the dopamine protocol (6.8 ml/kg) remained similar to the control protocol (4.1 ml/kg), and the phenylephrine protocol had a net volume loss (-1.9 ml/kg). Some blood volume expansion differences were attributed to changes in renal function as phenylephrine infusion increased urinary output, whereas isoproterenol was associated with antidiuresis. However, dopamine caused diuresis and sustained augmentation of blood volume. CONCLUSION: Catecholamines can alter the intravascular volume expansion of fluid therapy. beta-Receptor (isoproterenol) stimulation augmented blood volume expansion, whereas alpha (phenylephrine) stimulation reduced blood volume expansion. Combined dopaminergic, beta, and possibly alpha stimulation with dopamine augmented blood volume expansion and cardiac output while inducing diuresis.
Luiz A Vane; Donald S Prough; Michael A Kinsky; Chad A Williams; James J Grady; George C Kramer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  101     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-26     Completed Date:  2004-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1136-44     Citation Subset:  AIM; IM    
Department of Anesthesiology, University of Texas Medical Branch Galveston, USA.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Adrenergic beta-Agonists / pharmacology
Blood Pressure / drug effects
Blood Volume / drug effects*
Cardiac Output / drug effects
Cardiotonic Agents / pharmacology
Catecholamines / pharmacology*
Dopamine / pharmacology
Hemoglobins / metabolism
Isoproterenol / pharmacology
Isotonic Solutions
Phenylephrine / pharmacology
Plasma Substitutes / pharmacology*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic beta-Agonists; 0/Cardiotonic Agents; 0/Catecholamines; 0/Hemoglobins; 0/Isotonic Solutions; 0/Plasma Substitutes; 0/crystalloid solutions; 59-42-7/Phenylephrine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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