Document Detail


Effects of different LAD-blocked sites on the development of acute myocardial infarction and malignant arrhythmia in a swine model.
MedLine Citation:
PMID:  25276369     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To explore the effects of various left anterior descending (LAD) artery-blocked sites on the development of acute myocardial infarction (AMI) and malignant arrhythmia in a swine model.
METHODS: Twenty-two pigs underwent occlusion of the coronary artery with balloon angioplasty were randomly divided into three groups according to the blocked site of the balloon: middle-site-blocked LAD group, bottom-third-blocked LAD group and control group. Then, the development of AMI and malignant arrhythmia, including ventricular tachycardia and ventricular fibrillation during the process of model creation, were recorded. Changes of the hemodynamics, blood gas analysis, electrocardiography, and myocardial enzymes were analyzed in each group before and after occlusion.
RESULTS: Middle-site-LAD blockage resulted in a larger infarction size and the corresponding incidence of ventricular fibrillation was significantly higher than that of the bottom-third-blocked group (P<0.05). After the occlusion, the QTc interval of the Middle-site-blocked LAD group was significantly longer than that in the other groups (P<0.01). Moreover, mean arterial blood pressure (MAP), left ventricular ejection fraction (LVEF), and partial pressure of oxygen (PaO2) were significantly lower, but partial pressure of carbon dioxide (PaCO2) increased, in the Middle-site-blocked-LAD group compared with that in the bottom-third-blocked group (P<0.01). Compared with the control group, the two LAD-blocked groups showed significantly higher levels of Mb, CK-MB, LDH, AST and cTnT (P<0.01) four hours after the artery occlusion. However, these indexes were not significantly different between the two LAD-blocked groups (P>0.05).
CONCLUSIONS: Location of LAD blockages in swine models may affect the development of AMI and malignant arrhythmia.
Authors:
Xiaorong Li; Danbing Shao; Gannan Wang; Ting Jiang; Honghao Wu; Bing Gu; Kejiang Cao; Jinsong Zhang; Lianwen Qi; Yan Chen
Related Documents :
8158659 - "dose"-dependency and temporal characteristics of protection by ischaemic preconditioni...
10969309 - Prevention of isoflurane-induced preconditioning by 5-hydroxydecanoate and gadolinium: ...
8443909 - Loss of myocardial protection after preconditioning correlates with the time course of ...
8800449 - Limitation of infarct size with preconditioning and calcium antagonist (diltiazem): dif...
12902099 - Cardiomyocyte apoptosis and ischemic preconditioning in open heart operations.
9833149 - Mild hypothermia reduces infarct size in the beating rabbit heart: a practical interven...
19211269 - Massive acute infarction of the right ventricular wall without or only minimal infarcti...
8817399 - Calcium channel blockers in the dock: innocent or guilty?
7709399 - Early prediction of stroke severity. role of the erythrocyte sedimentation rate.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of thoracic disease     Volume:  6     ISSN:  2072-1439     ISO Abbreviation:  J Thorac Dis     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-10-03     Completed Date:  2014-10-03     Revised Date:  2014-10-04    
Medline Journal Info:
Nlm Unique ID:  101533916     Medline TA:  J Thorac Dis     Country:  China    
Other Details:
Languages:  eng     Pagination:  1271-7     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Elevated pretreatment serum globulin albumin ratio predicts poor prognosis for advanced non-small ce...
Next Document:  Adiponectin protects rat heart from left ventricular remodeling induced by chronic intermittent hypo...