Document Detail

Effects of diets containing fish oil and vitamin E on rheumatoid arthritis.
MedLine Citation:
PMID:  11669239     Owner:  NLM     Status:  MEDLINE    
Animal, tissue culture, and human studies have evaluated the effects of fish oil supplementation in patients with rheumatoid arthritis (RA) over the last two decades. These studies have clearly shown potentially beneficial changes in cytokine and eicosanoid metabolism. The overall clinical improvement, however, has been only moderate. European clinical trials have shown significant pain reduction in patients with RA treated with vitamin E. A recent animal study in RA-prone mice evaluated the effects of vitamin E in addition to omega-3 and omega-6 fatty acids on cytokine and eicosanoid production. The authors suggest that vitamin E might have an additional positive effect on autoimmune disease by decreasing proinflammatory cytokines and lipid mediators. Is this information ultimately important in terms of dietary advice for patients with RA? Are further clinical trials indicated? The following article will present a brief critical review.
S Tidow-Kebritchi; S Mobarhan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  59     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-23     Completed Date:  2001-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-8     Citation Subset:  IM    
Loyola University Medical Center, Maywood, IL 60153, USA.
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MeSH Terms
Arthritis, Rheumatoid / therapy*
Cytokines / metabolism
Eicosanoids / metabolism
Fish Oils / therapeutic use*
Meta-Analysis as Topic
Vitamin E / therapeutic use*
Reg. No./Substance:
0/Cytokines; 0/Eicosanoids; 0/Fish Oils; 1406-18-4/Vitamin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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