Document Detail

Effects of dietary tin and copper on rat hepatocellular antioxidant protection.
MedLine Citation:
PMID:  2399253     Owner:  NLM     Status:  MEDLINE    
The effects of dietary tin on copper status and on enzymes and metabolites involved in hepatocellular antioxidant protection were measured in rats fed copper-adequate or copper-deficient diets with glucose or fructose. Rats became copper-depleted after 4 weeks on diets containing less than 0.5 micrograms of copper/g as evidenced by significant decreases in liver copper and serum ceruloplasmin. Signs of copper deficiency occurred in copper-depleted rats fed diets containing 100 micrograms of tin/g. Significant effects of tin on liver glutathione peroxidase and superoxide dismutase activities and on liver iron and total glutathione concentrations were observed. Interactions between copper and tin on liver copper and iron and on liver superoxide dismutase and malondialdehyde production are reported. Adverse effects of feeding diets containing 100 micrograms of tin/g include (i) copper depletion in rats fed copper-adequate diets, (ii) accelerated development of copper deficiency in rats fed copper-deficient diets, and (iii) reduction in hepatocellular antioxidant protection.
M Reicks; J I Rader
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)     Volume:  195     ISSN:  0037-9727     ISO Abbreviation:  Proc. Soc. Exp. Biol. Med.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-10-18     Completed Date:  1990-10-18     Revised Date:  2007-11-02    
Medline Journal Info:
Nlm Unique ID:  7505892     Medline TA:  Proc Soc Exp Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  123-8     Citation Subset:  IM    
Division of Nutrition, U.S. Food and Drug Administration, Washington, DC 20204.
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MeSH Terms
Ceruloplasmin / analysis
Copper / analysis,  deficiency*
Glutathione / analysis
Glutathione Peroxidase / analysis
Hemoglobins / analysis
Iron / analysis
Liver / analysis,  enzymology,  metabolism*
Superoxide Dismutase / analysis
Tin / administration & dosage*
Trace Elements / administration & dosage*
Weight Gain
Reg. No./Substance:
0/Hemoglobins; 0/Trace Elements; 70-18-8/Glutathione; 7439-89-6/Iron; 7440-31-5/Tin; 7440-50-8/Copper; EC Peroxidase; EC Dismutase; EC

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