| Effects of dietary supplemented amino acids on endogenous hypercholesterolemia in rats. | |
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MedLine Citation:
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PMID: 2130151 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of additions of amino acids to a 20% casein diet on serum cholesterol (Ch) were studied in hypothyroid and hepatoma-bearing rats with endogenous hypercholesterolemia as well as in normal rats. In normal Wistar rats, methionine (Met) was hypercholesterolemic at the "nutritional" level (0.2-0.4%), but hypocholesterolemic at the "excess" level (1.2-2.4%). In Wistar rats with hypothyroidism induced by thiouracil, the addition of excess (1.2%) Met to the 20% casein diet reduced an endogenous hypercholesterolemia due to hypothyroidism by suppressing an elevation in (VLDL + LDL)-Ch with no significant influence on HDL-Ch. In Donryu rats received a subcutaneous implantation of AH109A cells (an ascites hepatoma line), either 1.2% Met, 1.2% cystine (Cys), or 1.2% Met and 2.5% glycine (Gly) in combination improved a hepatoma-induced hypercholesterolemia and abnormal serum lipoprotein profiles by suppressing a hepatoma-induced increase in (VLDL + LDL)-Ch. From Ch turnover studies in hepatoma-bearing rats, an impaired catabolism of Ch in the liver was suggested to be one cause for the hepatoma-induced elevation in (VLDL + LDL)-Ch. One of the dietary manipulations. met and Gly in combination (Met + Gly), was found to improve the impaired Ch catabolism, this leading to a reduction of the (VLDL + LDL)-Ch level by Met + Gly in hepatoma-bearing rats. |
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Authors:
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K Yagasaki; R Funabiki |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of nutritional science and vitaminology Volume: 36 Suppl 2 ISSN: 0301-4800 ISO Abbreviation: J. Nutr. Sci. Vitaminol. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1991-10-30 Completed Date: 1991-10-30 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0402640 Medline TA: J Nutr Sci Vitaminol (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: S165-8 Citation Subset: IM |
Affiliation:
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Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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administration & dosage,
pharmacology* Animals Caseins / administration & dosage, pharmacology Cystine / administration & dosage, pharmacology Dietary Proteins / administration & dosage, pharmacology* Glycine / administration & dosage, pharmacology Hypercholesterolemia / blood*, etiology Hypothyroidism / blood, chemically induced, complications Liver Neoplasms, Experimental / complications Male Methionine / administration & dosage, pharmacology Rats Rats, Inbred Strains Thiouracil |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Caseins; 0/Dietary Proteins; 141-90-2/Thiouracil; 56-40-6/Glycine; 56-89-3/Cystine; 63-68-3/Methionine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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