Document Detail

Effects of dietary supplementation with fish oil on atherosclerosis and myocardial injury during acute coronary occlusion-reperfusion in diet-induced hypercholesterolemic rabbits.
MedLine Citation:
PMID:  1612795     Owner:  NLM     Status:  MEDLINE    
We studied myocardial injury during acute coronary occlusion-reperfusion and atherosclerosis in rabbits fed a high cholesterol diet with or without fish oil supplementation. New Zealand white male rabbits were divided into 3 groups. Eight control rabbits fed with laboratory standard rabbit chow were group I. In addition to the standard chow, 15 rabbits fed with a 1% cholesterol-enriched diet for 6 weeks were group II, and 10 rabbits fed with a 1% cholesterol-enriched and 10% fish oil supplemented diet for 6 weeks were group III. Acute coronary occlusion was induced by ligating the marginal branch of the left circumflex coronary artery for 1 h, followed by reperfusion for 4 h. Myocardial injury was assessed by tissue creatine kinase activities and amino-nitrogen concentrations from the ischemic (infarct) and nonischemic (normal) myocardium, and the infarct area/risk area ratios of the left ventricle. The surface area of the atherosclerotic lesions of the aorta and pulmonary artery was measured by planimeter. There was significantly more myocardial loss of creatine kinase and amino-nitrogen in the cholesterol-fed rabbits than the controls (p less than 0.01 and 0.02, respectively). The cholesterol and fish oil-treated rabbits had a nonsignificant reduction in myocardial loss of both agents as compared to their corresponding cholesterol-fed ones. The same trend was also found in the infarct area/risk area ratio. Fish oil treated rabbits had a good effect on the reduction of atherosclerotic lesions and tissue cholesterol levels in the aorta and pulmonary artery, but not in the left ventricle.(ABSTRACT TRUNCATED AT 250 WORDS)
M F Chen; Y T Lee; H C Hsu; P C Yeh; C S Liau; P C Huang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cardiology     Volume:  35     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-30     Completed Date:  1992-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  323-31     Citation Subset:  IM    
Department of Internal Medicine (Cardiology), College of Medicine, National Taiwan University, Taipei.
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MeSH Terms
Amines / metabolism
Arteriosclerosis / etiology,  prevention & control*
Blood Pressure
Cholesterol, Dietary / administration & dosage
Creatine Kinase / metabolism
Fatty Acids / administration & dosage
Fish Oils / administration & dosage*
Heart Rate
Hypercholesterolemia / complications*
Lipids / blood
Myocardial Reperfusion Injury / physiopathology,  prevention & control*
Myocardium / metabolism
Nitrogen / metabolism
Reg. No./Substance:
0/Amines; 0/Cholesterol, Dietary; 0/Fatty Acids; 0/Fish Oils; 0/Lipids; 7727-37-9/Nitrogen; EC Kinase

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