Document Detail

Effects of dietary supplementation with arachidonic acid on platelet and renal function in patients with cirrhosis.
MedLine Citation:
PMID:  12877651     Owner:  NLM     Status:  MEDLINE    
Advanced cirrhosis is associated with reduced platelet function and altered renal function and sodium handling. Arachidonic acid (AA) metabolites contribute to platelet aggregation and to maintain the response to diuretics in advanced cirrhosis. In the present study, we tested the effects of a dietary supplementation for 8 weeks with a triacylglycerol (triglyceride) enriched in AA (ARASCO; 4 g/day) or oleic acid (OA) on plasma and membrane fatty acid composition, platelet aggregation and renal prostaglandin (PG) metabolism. At baseline, all patients had reduced platelet aggregation. Patients treated with AA showed a significant increase in the percentage of AA in plasma lipids and membrane phospholipids. These changes were associated with an increased platelet aggregation in response to collagen (from 55.83 +/- 20.63 to 67.67 +/- 14.44%; P<0.05). At baseline, all urinary AA metabolites, including PGE2, 6-keto-PGF1alpha, 8-epi-PGF2alpha and 11-dehydro-thromboxane B2, were elevated in cirrhotic patients when compared with a group of normal subjects. After furosemide treatment, urinary excretion of 11-dehydro-thromboxane B2 increased significantly. Supplementation with AA did not result in any significant change in urinary PG excretion either before or after diuretic administration. The results of the present study show that dietary supplementation with AA effectively increases the levels of this fatty acid in plasma and membrane phospholipids and improves platelet aggregation. These data suggest a possible novel approach to the treatment of the haemostatic defect observed in these patients.
Pietro Pantaleo; Fabio Marra; Francesco Vizzutti; Saura Spadoni; Giovanni Ciabattoni; Claudio Galli; Giorgio La Villa; Paolo Gentilini; Giacomo Laffi
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  106     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-11     Completed Date:  2004-02-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-34     Citation Subset:  IM    
Department of Internal Medicine, University of Florence, Viale Morgagni 85, I-50134 Florence, Italy.
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MeSH Terms
Arachidonic Acid / blood,  pharmacology*
Dietary Supplements*
Diuretics / therapeutic use
Double-Blind Method
Fatty Acids / blood
Furosemide / therapeutic use
Kidney / drug effects*,  physiopathology
Liver Cirrhosis / blood*,  drug therapy,  physiopathology
Middle Aged
Phospholipids / blood
Platelet Aggregation / drug effects*
Prostaglandins / urine
Reg. No./Substance:
0/Diuretics; 0/Fatty Acids; 0/Phospholipids; 0/Prostaglandins; 506-32-1/Arachidonic Acid; 54-31-9/Furosemide

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