| Effects of dietary sodium deprivation on erythrocyte sodium concentration and cation transport in normotensive and untreated hypertensive subjects. | |
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MedLine Citation:
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PMID: 2420863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is controversy about the effects of dietary sodium deprivation on cellular cation transport. Using washed erythrocytes for in vitro 22Na and 86Rb uptake studies, we studied the effects of a strict low-salt diet (20 mmol/day) for 4 days in 14 normotensive and 13 hypertensive subjects. Urinary sodium excretion fell from 147 +/- 13 to 18 +/- 3 mmol/24 h in the normotensive group and from 155 +/- 16 to 20 +/- 2 mmol/24 h in the hypertensive group. In both groups, there was a fall in plasma sodium concentration and activation of the renin-aldosterone axis. Both systolic and diastolic blood pressures fell in the hypertensive, but not the normotensive group. There were small but significant (P less than 0.025) decreases in cell cation concentrations and passive cation transport in the normotensive, but not the hypertensive group. No significant change in sodium pump activity or in Na+K+ cotransport was seen in either group. These observations provide no support for the concept that a decrease in dietary sodium intake can induce changes in cell cation transport, detectable in vitro, to which reduction in blood pressure may be attributed. |
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Authors:
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G S Stokes; J C Monaghan; A T Middleton; M Shirlow; J F Marwood |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 4 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1986 Feb |
Date Detail:
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Created Date: 1986-05-07 Completed Date: 1986-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 35-8 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Transport, Active Diet, Sodium-Restricted* Erythrocytes / metabolism* Female Humans Hypertension / blood*, diet therapy Ion Channels / metabolism Male Middle Aged Potassium / blood Rubidium / blood Sodium / blood* |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 7440-09-7/Potassium; 7440-17-7/Rubidium; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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