| Effects of dietary quillaja saponin and curcumin on the performance and immune status of weaned piglets. | |
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MedLine Citation:
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PMID: 15583046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of this study was to determine whether dietary quillaja saponin and curcumin (extract of turmeric) can modify piglet immune status and performance immediately after weaning. Piglets (n = 192) were weaned at 29 +/- 0.1 d and allocated to treatment (six replicates of eight pig per treatment) accounting for weight, litter, and gender, using a 2 x 2 factorial arrangement. Factors were diets with or without (as-fed basis) quillaja saponin (750 mg/kg during wk 1, 300 mg/kg during wk 2 to 3) and with or without dietary curcumin (200 mg/kg). Diets were fed ad libitum for 20 d after weaning. Feed intake was measured daily. Piglets were weighed at weaning, d 7, 14, and 20 after weaning. On each of d 6 and 20 after weaning, eight pigs per treatment were sacrificed for blood and tissue collection. Treatment had no effect on piglet growth. The ADFI and G:F were similar for all treatments between d 0 and 14 of the trial. Between d 15 and 20, ADFI and G:F were lower in quillaja-supplemented piglets (ADFI = 621 vs. 572 g/d; G:F = 0.75 vs. 0.85; P < 0.05). Serum immunoglobulin (Ig) G, IgA, interferon-gamma, and C-reactive protein (CRP) did not differ among treatments on d 6 after weaning. On d 20, IgG and CRP were greater (P < 0.05) in saponin-supplemented pigs (IgG = 17.5 vs. 11.4 mg/mL; CRP = 26.98 vs. 12.5 mg/mL). Small intestine villus and crypt measurements did not differ among treatments on either d 6 or 20. Saponin supplementation during the postweaning period seemed to potentiate an immune response in the weaned piglet but had a detrimental effect on the utilization of feed. Dietary curcumin had no influence on any measured aspect of pig performance or immune status. |
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Authors:
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S E Ilsley; H M Miller; C Kamel |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of animal science Volume: 83 ISSN: 1525-3163 ISO Abbreviation: J. Anim. Sci. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-07 Completed Date: 2007-10-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8003002 Medline TA: J Anim Sci Country: United States |
Other Details:
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Languages: eng Pagination: 82-8 Citation Subset: IM |
Affiliation:
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School of Biology, University of Leeds, UK. sian@ilsley50.freeserve.co.uk <sian@ilsley50.freeserve.co.uk> |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animal Feed
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analysis Animals Anti-Bacterial Agents / therapeutic use C-Reactive Protein / analysis, drug effects Curcumin / administration & dosage, pharmacology* Dietary Supplements* Eating / drug effects Female Immunoglobulin A / blood, drug effects Immunoglobulin G / blood, drug effects Interferon-gamma / blood, drug effects Intestine, Small / drug effects Male Plant Extracts / pharmacology Quillaja / physiology* Random Allocation Swine / growth & development*, immunology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Immunoglobulin A; 0/Immunoglobulin G; 0/Plant Extracts; 458-37-7/Curcumin; 82115-62-6/Interferon-gamma; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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