Document Detail

Effects of dietary protein restriction and oil type on the early progression of murine polycystic kidney disease.
MedLine Citation:
PMID:  1453579     Owner:  NLM     Status:  MEDLINE    
A paucity of research data exists on the potential for early dietary modification to directly retard cystic growth and proliferation in polycystic kidney disease (PKD). We have therefore examined the relative effects of dietary protein levels and oil type on the progression of disease in a murine model of PKD. In the first study, weanling DBA/2FG-pcy (pcy) mice were fed either a normal (NP), 25%, or low (LP), 6%, casein diet with 10% of either sunflower seed oil (SO) (containing n-6 fatty acids), or fish oil (FO) (containing n-3 fatty acids), in a 2 x 2 design. At the end of the dietary treatment, kidney weight relative to body weight was higher in mice on the NP diets. In addition, kidney phospholipid to kidney weight (mumol/g) was lower in pcy mice on NP diets, indicating that the increased kidney size was largely due to increased cyst development. Replacement of dietary SO with FO resulted in alterations in renal phospholipid fatty acid compositions: 18:2 n-6, 20:4 n-6, and 22:5 n-6 were lower, and 20:5 n-3, 22:5 n-3, and 22:6 n-3 were higher in FO-fed animals. No effect of dietary lipid type on disease progression was noted, however. In a second study, morphometric analysis revealed an 11% lower percentage cyst area and a 46% lower total cyst area (mm2) in kidney sections derived from mice on LP diets compared to NP diets. These results indicate that early dietary protein restriction in PKD prior to clinical manifestation of symptoms of the disease may have a significant impact on the pathogenesis of PKD.
H M Aukema; M R Ogborn; K Tomobe; H Takahashi; T Hibino; B J Holub
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  42     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1993-01-07     Completed Date:  1993-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  837-42     Citation Subset:  IM    
Department of Nutritional Sciences, University of Guelph, Ontario, Canada.
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MeSH Terms
Body Weight
Dietary Fats, Unsaturated / administration & dosage*
Dietary Proteins / administration & dosage*
Fatty Acids / analysis
Kidney / chemistry,  pathology
Mice, Inbred DBA
Organ Size
Polycystic Kidney, Autosomal Dominant / pathology*
Reg. No./Substance:
0/Dietary Fats, Unsaturated; 0/Dietary Proteins; 0/Fatty Acids

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