| Effects of dietary polyamines and clofibrate on metabolism of polyamines in the rat. | |
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MedLine Citation:
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PMID: 15539269 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The activities of catalase, polyamine oxidase, diamine oxidase, ornithine decarboxylase, and peroxisomal beta-oxidation were assayed in homogenates from liver and small intestinal mucosa of rats which had been fed either a diet very low in polyamines or a diet containing five times the levels of dietary polyamines (putrescine, spermine, and spermidine) found in a standard rat diet. In rats fed the high polyamine diet, hepatic activities of catalase and polyamine oxidase were significantly decreased. Levels of the other activities were unchanged, except that intestinal ornithine decarboxylase was decreased. In rats treated simultaneously with clofibrate, the high polyamine diet restored activities of catalase, ornithine decarboxylase, and polyamine oxidase back to levels found in rats fed the low polyamine diet. The expected increase in activity of peroxisomal beta-oxidation was observed, although this was somewhat diminished in rats fed the high polyamine diet. Intestinal diamine oxidase activity was stimulated by clofibrate, particularly in rats fed the high polyamine diet. For the duration of the experiment (20 days), levels of putrescine, spermine, and spermidine in blood remained remarkably constant irrespective of treatment, suggesting that polyamine homeostasis is essentially independent of dietary supply of polyamines. It is suggested that intestinal absorption/metabolism of polyamines is of significance in this respect. Treatment with clofibrate appeared to alter polyamine homeostasis. |
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Authors:
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B P Brodal; K A Eliassen; H Rönning; H Osmundsen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 10 ISSN: 0955-2863 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2004-11-12 Completed Date: 2005-03-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 700-8 Citation Subset: - |
Affiliation:
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Department of Oral Biology, University of Oslo, Oslo, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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