Document Detail


Effects of dietary lutein and PUFA on PPAR and RXR isomer expression in chickens during an inflammatory response.
MedLine Citation:
PMID:  20601055     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the effects of dietary lutein and polyunsaturated fatty acids (PUFA) on the total lutein and lipid levels, the peroxisome proliferators activated receptors (PPAR) alpha and gamma, retinoic acid X receptor (RXR) alpha and gamma and IL-1 mRNA levels in chicken (Gallus gallus) liver and spleen. In experiment I, chickens were fed either 0, 25 or 50mg lutein in a diet with 3% PUFA fat. In experiment II, chickens were fed either 3 or 6% PUFA fat with 25mg lutein. At 23d of age, chickens were injected with LPS. LPS injection decreased the lutein content and increased the fat content in the liver and spleen in both experiments. Increasing dietary PUFA fat to 6% ameliorated the LPS-induced lutein depletion in experiment II. LPS injection increased IL-1 and decreased splenic PPARalpha, PPARgamma, RXRalpha mRNA in experiment I and II. The LPS-induced PPARalpha and RXRalpha downregulation were partially reversed by increasing the dietary lutein content to 50mg/kg feed in experiment I and by increasing the dietary PUFA fat content to 6% in experiment II. Increasing dietary lutein content to 50mg/kg feed increased PPARgamma mRNA amount only in the LPS untreated groups in experiment I. Increasing dietary PUFA fat or LPS injection in the 6% PUFA fat group upregulated PPARgamma mRNA in experiment II. Increasing dietary PUFA fat to 6% blunted the increase in IL-1 mRNA due to LPS. It is concluded that dietary lutein and PUFA fat were anti-inflammatory due to modification of immune tissue lutein content, PPAR, RXR isomers and IL-1beta mRNA levels in liver and spleen.
Authors:
Ramesh K Selvaraj; Revathi Shanmugasundaram; Kirk C Klasing
Related Documents :
1411255 - Long-term supplementation with n-3 fatty acids, ii: effect on neutrophil and monocyte c...
19148125 - Prevention and reversal of obesity and glucose intolerance in mice by dha derivatives.
8066095 - N-3 fatty acids reduce in vitro thromboxane production while having little effect on in...
20206485 - Elevated plasma fibrinogen caused by inadequate alpha-linolenic acid intake can be redu...
1797205 - Additive effects of dietary protein and energy deficiencies on diaphysis and bone tissu...
16484555 - Homocysteine-lowering action is another potential cardiovascular protective factor of a...
Publication Detail:
Type:  Journal Article     Date:  2010-06-23
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  157     ISSN:  1531-4332     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  198-203     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
Department of Animal Sciences, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH 44691, USA. selvaraj.7@osu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Chickens
Diet
Dietary Fats / pharmacology*
Fatty Acids, Unsaturated / pharmacology*
Inflammation / chemically induced,  metabolism*
Lipopolysaccharides
Liver / drug effects,  metabolism
Lutein / pharmacology*
Peroxisome Proliferator-Activated Receptors / biosynthesis*
Retinoid X Receptors / biosynthesis*
Spleen / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Unsaturated; 0/Lipopolysaccharides; 0/Peroxisome Proliferator-Activated Receptors; 0/Retinoid X Receptors; 127-40-2/Lutein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nematocyst discharge in Hydra vulgaris: Differential responses of desmonemes and stenoteles to mecha...
Next Document:  Hsp70 expression and metabolite composition in response to short-term thermal changes in Folsomia ca...