| Effects of dietary inorganic nitrate on static and dynamic breath-holding in humans. | |
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MedLine Citation:
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PMID: 23099220 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Inorganic nitrate has been shown to reduce oxygen cost during exercise. Since the nitrate-nitrite-NO pathway is facilitated during hypoxia, we investigated the effects of dietary nitrate on oxygen consumption and cardiovascular responses during apnea. These variables were measured in two randomized, double-blind, placebo-controlled, crossover protocols at rest and ergometer exercise in competitive breath-hold divers. Subjects held their breath for predetermined times along with maximum effort apneas after two separate 3-day periods with supplementation of potassium nitrate/placebo. In contrast to our hypothesis, nitrate supplementation led to lower arterial oxygen saturation (SaO(2), 77±3%) compared to placebo (80±2%) during static apnea, along with lower end-tidal fraction of oxygen (FETO(2)) after 4min of apnea (nitrate 6.9±0.4% vs. placebo 7.6±0.4%). Maximum apnea duration was shorter after nitrate (329±13s) compared to placebo (344±13s). During cycle ergometry nitrate had no effect on SaO(2), FETO(2) or maximum apnea duration. The negative effects of inorganic nitrate during static apnea may be explained by an attenuated diving response. |
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Authors:
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Tomas A Schiffer; Filip J Larsen; Jon O Lundberg; Eddie Weitzberg; Peter Lindholm |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-22 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: - ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address: tomas.schiffer@ki.se. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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