| Effects of dietary fatty-acid supplementation on fatty-acid composition and deformability of young and old erythrocytes. | |
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MedLine Citation:
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PMID: 8323949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of cell age on erythrocyte phospholipid fatty-acid composition and deformability were examined in 20 healthy adults (11 male, 9 female) prior to and following 12 weeks of dietary supplementation with 3.5 g/day of safflower oil (high in n - 6 fatty acids) or fish oil (high in n - 3 fatty acids). In the absence of dietary supplementation, old erythrocytes demonstrated an increase in filtration time (P < 0.001), an increase in membrane phospholipid total n - 6 fatty acids (P < 0.01), and a decrease in total n - 3/total n - 6 ratio (P < 0.01) compared to young erythrocytes. Both safflower and fish oil supplementation attenuated age-related differences in membrane phospholipid total n - 6 and total n - 3 fatty acids. Fish oil supplementation also increased the proportion of n - 3 fatty acids (P < 0.01) and the n - 3/n - 6 ratio (P < 0.05) in the phospholipids of both young and old erythrocytes, and eliminated age-related differences in erythrocyte filtration time by reducing the relative filtration time of the old erythrocytes. |
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Authors:
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D E Mills; W R Galey; H Dixon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1149 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-08-12 Completed Date: 1993-08-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 313-8 Citation Subset: IM |
Affiliation:
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Department of Health Studies, University of Waterloo, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cell Size Dietary Fats, Unsaturated / pharmacology* Erythrocyte Aging Erythrocytes / chemistry, metabolism* Fatty Acids / analysis Fatty Acids, Omega-3 / pharmacology* Fatty Acids, Omega-6 Fatty Acids, Unsaturated / pharmacology* Female Fish Oils Humans Male Phospholipids / chemistry Safflower Oil Water / analysis |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats, Unsaturated; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Phospholipids; 7732-18-5/Water; 8001-23-8/Safflower Oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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