Document Detail

Effects of dietary fat quality and quantity on postprandial activation of blood coagulation factor VII.
MedLine Citation:
PMID:  9409274     Owner:  NLM     Status:  MEDLINE    
Acute elevation of the coagulant activity of blood coagulation factor VII (FVIIc) is observed after consumption of high-fat meals. This elevation is caused by an increase in the concentration of activated FVII (FVIIa). In a randomized crossover study, we investigated whether saturated, monounsaturated, or polyunsaturated fats differed regarding postprandial activation of FVII. Eighteen healthy young men participated in the study. On 6 separate days each participant consumed two meals (times, 0 and 1 3/4 hours) enriched with 70 g (15 and 55 g) of either rapeseed oil, olive oil, sunflower oil, palm oil, or butter (42% of energy from fat) or isoenergetic low-fat meals (6% of energy from fat). Fasting and series of nonfasting blood samples (the last at time 8 1/2 hours) were collected. Plasma triglycerides, FVIIc, FVIIa, and free fatty acids were analyzed. There were marked effects of the fat quantity on postprandial responses of plasma triglycerides, FVII, and free fatty acids. The high-fat meals caused, in contrast to the low-fat meals, considerable increases in plasma triglycerides. Plasma levels of FVIIc and FVIIa peaks were 7% and 60% higher after consumption of high-fat meals than after consumption of low-fat meals. The five different fat qualities caused similar postprandial increases in plasma triglycerides, FVIIc, and FVIIa. These findings indicate that high-fat meals may be prothrombotic, irrespective of their fatty acid composition. The postprandial FVII activation was not associated with the plasma triglyceride or free fatty acid responses.
L F Larsen; E M Bladbjerg; J Jespersen; P Marckmann
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  17     ISSN:  1079-5642     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-22     Completed Date:  1998-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2904-9     Citation Subset:  IM    
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
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MeSH Terms
Cross-Over Studies
Dietary Fats / administration & dosage,  pharmacology*
Double-Blind Method
Energy Intake
Factor VII / metabolism*
Factor VIIa / biosynthesis*
Fatty Acids, Monounsaturated / pharmacology
Fatty Acids, Nonesterified / pharmacology
Fatty Acids, Omega-6
Fatty Acids, Unsaturated / pharmacology
Plant Oils / pharmacology
Thrombosis / etiology
Triglycerides / blood
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Plant Oils; 0/Triglycerides; 8001-21-6/sunflower seed oil; 8001-25-0/olive oil; 8002-13-9/rapeseed oil; 8002-75-3/palm oil; 8029-34-3/Butter; 9001-25-6/Factor VII; EC VIIa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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