Document Detail

Effects of dietary fat modification on oxidative stress and inflammatory markers in the LIPGENE study.
MedLine Citation:
PMID:  20569506     Owner:  NLM     Status:  MEDLINE    
Subjects with the metabolic syndrome (MetS) have enhanced oxidative stress and inflammation. Dietary fat quality has been proposed to be implicated in these conditions. We investigated the impact of four diets distinct in fat quantity and quality on 8-iso-PGF2α (a major F2-isoprostane and oxidative stress indicator), 15-keto-13,14-dihydro-PGF2α (15-keto-dihydro-PGF2α, a major PGF2α metabolite and marker of cyclooxygenase-mediated inflammation) and C-reactive protein (CRP). In a 12-week parallel multicentre dietary intervention study (LIPGENE), 417 volunteers with the MetS were randomly assigned to one of the four diets: two high-fat diets (38 % energy (%E)) rich in SFA or MUFA and two low-fat high-complex carbohydrate diets (28 %E) with (LFHCC n-3) or without (LFHCC) 1·24 g/d of very long chain n-3 fatty acid supplementation. Urinary levels of 8-iso-PGF2α and 15-keto-dihydro-PGF2α were determined by RIA and adjusted for urinary creatinine levels. Serum concentration of CRP was measured by ELISA. Neither concentrations of 8-iso-PGF2α and 15-keto-dihydro-PGF2α nor those of CRP differed between diet groups at baseline (P>0·07) or at the end of the study (P>0·44). Also, no differences in changes of the markers were observed between the diet groups (8-iso-PGF2α, P = 0·83; 15-keto-dihydro-PGF2α, P = 0·45; and CRP, P = 0·97). In conclusion, a 12-week dietary fat modification did not affect the investigated markers of oxidative stress and inflammation among subjects with the MetS in the LIPGENE study.
Helena Petersson; Ulf Risérus; Jolene McMonagle; Hanne L Gulseth; Audrey C Tierney; Sophie Morange; Olfa Helal; Danielle I Shaw; Juan A Ruano; José López-Miranda; Beata Kieć-Wilk; Iwona Gołąbek; Ellen E Blaak; Wim H M Saris; Christian A Drevon; Julie A Lovegrove; Helen M Roche; Samar Basu
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-06-23
Journal Detail:
Title:  The British journal of nutrition     Volume:  104     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  1357-62     Citation Subset:  IM    
Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden.
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MeSH Terms
Biological Markers / metabolism
C-Reactive Protein / metabolism*
Diet, Fat-Restricted
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage*
Dietary Supplements
Dinoprost / analogs & derivatives,  urine*
Enzyme-Linked Immunosorbent Assay
Fatty Acids / pharmacology*,  therapeutic use
Food Habits
Inflammation / diet therapy,  metabolism*
Metabolic Syndrome X / diet therapy,  metabolism*
Middle Aged
Oxidative Stress / drug effects*
Reg. No./Substance:
0/Biological Markers; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Fatty Acids; 551-11-1/Dinoprost; 9007-41-4/C-Reactive Protein

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