Document Detail

Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome-LIPGENE: a European randomized dietary intervention study.
MedLine Citation:
PMID:  20938439     Owner:  NLM     Status:  In-Data-Review    
Background:Excessive energy intake and obesity lead to the metabolic syndrome (MetS). Dietary saturated fatty acids (SFAs) may be particularly detrimental on insulin sensitivity (SI) and on other components of the MetS.Objective:This study determined the relative efficacy of reducing dietary SFA, by isoenergetic alteration of the quality and quantity of dietary fat, on risk factors associated with MetS.Design:A free-living, single-blinded dietary intervention study.Subjects and Methods:MetS subjects (n=417) from eight European countries completed the randomized dietary intervention study with four isoenergetic diets distinct in fat quantity and quality: high-SFA; high-monounsaturated fatty acids and two low-fat, high-complex carbohydrate (LFHCC) diets, supplemented with long chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs) (1.2 g per day) or placebo for 12 weeks. SI estimated from an intravenous glucose tolerance test (IVGTT) was the primary outcome measure. Lipid and inflammatory markers associated with MetS were also determined.Results:In weight-stable subjects, reducing dietary SFA intake had no effect on SI, total and low-density lipoprotein cholesterol concentration, inflammation or blood pressure in the entire cohort. The LFHCC n-3 PUFA diet reduced plasma triacylglycerol (TAG) and non-esterified fatty acid concentrations (P<0.01), particularly in men.Conclusion:There was no effect of reducing SFA on SI in weight-stable obese MetS subjects. LC n-3 PUFA supplementation, in association with a low-fat diet, improved TAG-related MetS risk profiles.
A C Tierney; J McMonagle; D I Shaw; H L Gulseth; O Helal; W H M Saris; J A Paniagua; I Gołąbek-Leszczyñska; C Defoort; C M Williams; B Karsltröm; B Vessby; A Dembinska-Kiec; J López-Miranda; E E Blaak; C A Drevon; M J Gibney; J A Lovegrove; H M Roche
Related Documents :
9888649 - Dietary interventions affecting chylomicron and chylomicron remnant clearance.
16477809 - Effect of dietary n-6 and n-3 polyunsaturated fatty acids on peroxidizability of lipopr...
12207839 - Effects of dietary lipids on immune function in a murine sensitisation model.
20134159 - Moderate or supranormal folic acid supplementation does not exert a protective effect f...
15835259 - Dietary n-3 and n-6 fatty acids alter avian glucose metabolism.
12908899 - Dietary docosahexaenoic acid-induced production of tissue lipid peroxides is not suppre...
7324779 - Energy, fat and nitrogen balance in healthy newborn infants during the first week after...
12361489 - Dietary cholesterol and coronary heart disease.
1988169 - Effect of dietary iron deficiency or excess on the induction of mammary carcinogenesis ...
Publication Detail:
Type:  Journal Article     Date:  2010-10-12
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  35     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  800-9     Citation Subset:  IM    
Nutrigenomics Research Group, UCD Conway Institute & UCD Institute of Food & Health, University College Dublin, Belfield, Dublin 4, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of lupin-enriched foods on body composition and cardiovascular disease risk factors: a 12-mo...
Next Document:  Pigment epithelium-derived factor (PEDF) is one of the most abundant proteins secreted by human adip...