Document Detail

Effects of dietary coenzyme Q10 supplementation on hepatic mitochondrial function and the activities of respiratory chain-related enzymes in ascitic broiler chickens.
MedLine Citation:
PMID:  16359119     Owner:  NLM     Status:  MEDLINE    
1. One hundred and sixty 1-d-old Arbor Acre male broiler chicks were fed with maize-soybean based diets for 6 weeks in a 2 x 2 factorial experiment. The factors were CoQ10 supplementation (0 or 40 mg/kg) and Escherichia coli lipopolysaccharide (LPS) challenge (LPS or saline). 2. CoQ10 was supplemented from d 1. From d 18, the chickens received three weekly i.p. injections of LPS (1.0 mg/kg BW) or an equivalent amount of sterile saline as control. From d 10 on, all chickens were exposed to low ambient temperature (12 to 15 degrees C) to induce ascites. 3. The blood packed cell volume and ascites heart index of broiler chickens were reduced by dietary CoQ10 supplementation. Mitochondrial State 3 and State 4 respiration, respiratory control ratio and phosphate oxygen ratio were not changed, but H+/site stoichiometry of complex II + III was elevated by dietary CoQ10 supplementation. 4. Cytochrome c oxidase and H+-ATPase activity were increased by CoQ10 supplementation, whereas NADH cytochrome c reductase and succinate cytochrome c reductase were not influenced. Mitochondrial anti-ROS capability was increased and malondialdehyde content was decreased by CoQ10 supplementation. 5. The work suggested that dietary CoQ10 supplementation could reduce broiler chickens' susceptibility to ascites, which might be the result of improving hepatic mitochondrial function, some respiratory chain-related enzymes activities and mitochondrial antioxidative capability.
A L Geng; Y M Guo
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Publication Detail:
Type:  Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British poultry science     Volume:  46     ISSN:  0007-1668     ISO Abbreviation:  Br. Poult. Sci.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  15740290R     Medline TA:  Br Poult Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  626-34     Citation Subset:  IM    
Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing.
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MeSH Terms
Animal Feed
Ascites / chemically induced,  enzymology*,  pathology,  veterinary*
Dietary Supplements
Electron Transport / drug effects
Electron Transport Chain Complex Proteins / metabolism*
Lipopolysaccharides / toxicity
Mitochondria, Liver / drug effects*,  enzymology,  metabolism
Poultry Diseases / chemically induced,  enzymology*,  pathology*
Ubiquinone / administration & dosage,  analogs & derivatives*,  pharmacology
Reg. No./Substance:
0/Coenzymes; 0/Electron Transport Chain Complex Proteins; 0/Lipopolysaccharides; 1339-63-5/Ubiquinone; 303-98-0/coenzyme Q10

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