| Effects of dietary carbohydrate restriction versus low-fat diet on flow-mediated dilation. | |
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MedLine Citation:
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PMID: 19632695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported that a carbohydrate-restricted diet (CRD) ameliorated many of the traditional markers associated with metabolic syndrome and cardiovascular risk compared with a low-fat diet (LFD). There remains concern how CRD affects vascular function because acute meals high in fat have been shown to impair endothelial function. Here, we extend our work and address these concerns by measuring fasting and postprandial vascular function in 40 overweight men and women with moderate hypertriacylglycerolemia who were randomly assigned to consume hypocaloric diets (approximately 1500 kcal) restricted in carbohydrate (percentage of carbohydrate-fat-protein = 12:59:28) or LFD (56:24:20). Flow-mediated dilation of the brachial artery was assessed before and after ingestion of a high-fat meal (908 kcal, 84% fat) at baseline and after 12 weeks. Compared with the LFD, the CRD resulted in a greater decrease in postprandial triacylglycerol (-47% vs -15%, P = .007), insulin (-51% vs -6%, P = .009), and lymphocyte (-12% vs -1%, P = .050) responses. Postprandial fatty acids were significantly increased by the CRD compared with the LFD (P = .033). Serum interleukin-6 increased significantly over the postprandial period; and the response was augmented in the CRD (46%) compared with the LFD (-13%) group (P = .038). After 12 weeks, peak flow-mediated dilation at 3 hours increased from 5.1% to 6.5% in the CRD group and decreased from 7.9% to 5.2% in the LFD group (P = .004). These findings show that a 12-week low-carbohydrate diet improves postprandial vascular function more than a LFD in individuals with atherogenic dyslipidemia. |
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Authors:
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Jeff S Volek; Kevin D Ballard; Ricardo Silvestre; Daniel A Judelson; Erin E Quann; Cassandra E Forsythe; Maria Luz Fernandez; William J Kraemer |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-07-25 |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 58 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-11-16 Completed Date: 2009-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1769-77 Citation Subset: IM |
Affiliation:
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Department of Kinesiology and the Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-1110, USA. jeff.volek@uconn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Circulation / physiology Brachial Artery / anatomy & histology, physiology Diet, Carbohydrate-Restricted* Diet, Fat-Restricted* Dietary Fats / metabolism Fatty Acids, Nonesterified / blood Female Humans Insulin / blood Insulin Resistance / physiology Interleukin-6 / metabolism Leukocytes / drug effects Lipids / blood Male Middle Aged Postprandial Period / physiology Triglycerides / metabolism Vasodilation / physiology* Weight Loss / physiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids, Nonesterified; 0/Interleukin-6; 0/Lipids; 0/Triglycerides; 11061-68-0/Insulin |
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