| Effects of dietary calcium and phosphate on the intestinal interactions between calcium, phosphate, fatty acids, and bile acids. | |
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MedLine Citation:
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PMID: 8472985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Luminal free fatty acids and bile acids may damage the colonic epithelium and stimulate proliferation, which may increase the risk of colon cancer. It has been suggested that only soluble calcium ions (Ca2+) precipitate fatty acids and bile acids, thus reducing their lytic activity. Consequently, precipitation of luminal Ca2+ by dietary phosphate should inhibit these effects. To evaluate the proposed antagonistic effects of dietary calcium and phosphate, we studied the intestinal interactions between calcium, phosphate, fatty acids, and bile acids in rats fed purified diets that differed only in the concentrations of calcium and phosphate. Increased dietary calcium drastically decreased the solubility of fatty acids in the ileum, colon, and faeces, as well as the solubility of bile acids in the colon and faeces. Although dietary calcium strongly increased the total faecal fatty acid concentration and hardly affected the total faecal bile acid concentration, the fatty acid and bile acid concentrations in faecal water were drastically decreased by dietary calcium. Consequently, the lytic activity of faecal water was decreased. Dietary phosphate did not interfere with these intestinal effects of calcium. These results indicate that dietary phosphate does not inhibit the protective effects of dietary calcium on luminal solubility and the lytic activity of fatty and bile acids. |
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Authors:
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M J Govers; R Van der Meet |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gut Volume: 34 ISSN: 0017-5749 ISO Abbreviation: Gut Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-05-19 Completed Date: 1993-05-19 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985108R Medline TA: Gut Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 365-70 Citation Subset: AIM; IM |
Affiliation:
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Department of Nutrition, Netherlands Institute for Dairy Research, Ede. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / metabolism* Calcium, Dietary / metabolism, pharmacology* Colon / metabolism Drug Interactions Fatty Acids / metabolism* Feces / chemistry Female Gastrointestinal Contents / chemistry Intestine, Small / metabolism Phosphates / metabolism, pharmacology* Rats Rats, Wistar Solubility |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Calcium, Dietary; 0/Fatty Acids; 0/Phosphates |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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