| Effects of dietary amino acids on brain amino acids and transmitter amines in rats with a portacaval shunt. | |
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MedLine Citation:
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PMID: 6161235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The etiologic relationship between disturbances in metabolism of amino acids and amines and hepatic coma was investigated by examining the effects of diets containing various mixtures of amino acids on brain amine metabolism in rats with a portacaval shunt, using a method for simultaneous analysis of amino acids and amines. Rats with a portacaval shunt were fed on four different amino acid compositions with increased amounts of various amino acids suspected to be etiologically related to hepatic coma, such as methionine, phenylalanine, tyrosine, and tryptophan. The animals were killed 4 weeks after operation. During the experimental period, these animals did not become comatose, but exhibited various behavioral abnormalities. Marked increase in the plasma and brain levels of the augmented amino acids, especially methionine and tyrosine, were observed in rats with a portacaval shunt. Brain noradrenaline, dopamine, and serotonin levels were significantly decreased when the brain tyrosine level was increased. These results indicate that in rats with a portacaval shunt the dietary levels of amino acids greatly influence the brain levels of both amino acids and transmitter amines. |
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Authors:
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S Kamata; A Okada; T Watanabe; Y Kawashima; H Wada |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurochemistry Volume: 35 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1980 Nov |
Date Detail:
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Created Date: 1981-03-24 Completed Date: 1981-03-24 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1190-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
/
administration & dosage,
blood,
metabolism* Animals Brain / metabolism* Diet Dopamine / metabolism Hepatic Encephalopathy / chemically induced Hydroxyindoleacetic Acid / metabolism* Male Neurotransmitter Agents / metabolism* Norepinephrine / metabolism Portacaval Shunt, Surgical Rats Serotonin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Neurotransmitter Agents; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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