| Effects of dietary amines on the gut and its vasculature. | |
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MedLine Citation:
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PMID: 19017420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trace amines, including tyramine and beta-phenylethylamine (beta-PEA), are constituents of many foods including chocolate, cheeses and wines and are generated by so-called 'friendly' bacteria such as Lactobacillus, Lactococcus and Enterococcus species, which are found in probiotics. We therefore examined whether these dietary amines could exert pharmacological effects on the gut and its vasculature. In the present study we examined the effects of tyramine and beta-PEA on the contractile activity of guinea-pig and rat ileum and upon the isolated mesenteric vasculature and other blood vessels. Traditionally, these amines are regarded as sympathomimetic amines, exerting effects through the release of noradrenaline from sympathetic nerve endings, which should relax the gut. A secondary aim was therefore to confirm this mechanism of action. However, contractile effects were observed in the gut and these were independent of noradrenaline, acetylcholine, histamine and serotonin receptors. They were therefore probably due to the recently described trace amine-associated receptors. These amines relaxed the mesenteric vasculature. In contrast, the aorta and coronary arteries were constricted, a response that was also independent of a sympathomimetic action. From these results, we propose that after ingestion, trace amines could stimulate the gut and improve intestinal blood flow. Restriction of blood flow elsewhere diverts blood to the gut to aid digestion. Thus, trace amines in the diet may promote the digestive process through stimulation of the gut and improved gastrointestinal circulation. |
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Authors:
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Kenneth J Broadley; M Akhtar Anwar; Amy A Herbert; Martina Fehler; Elen M Jones; Wyn E Davies; Emma J Kidd; William R Ford |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-19 |
Journal Detail:
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Title: The British journal of nutrition Volume: 101 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-12 Completed Date: 2009-07-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1645-52 Citation Subset: IM |
Affiliation:
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Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cathays Park, Cardiff CF10 3NB, UK. broadleykj@cardiff.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amines
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pharmacology* Animals Aorta / drug effects, physiology Coronary Vessels / drug effects, physiology Diet* Dose-Response Relationship, Drug Electric Stimulation Guinea Pigs Ileum / blood supply, drug effects*, physiology Male Muscle Contraction / drug effects Phenethylamines / pharmacology Rats Rats, Sprague-Dawley Splanchnic Circulation / drug effects Swine Tissue Culture Techniques Tyramine / pharmacology Vasoconstriction / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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//British Heart Foundation; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Amines; 0/Phenethylamines; 51-67-2/Tyramine; 64-04-0/phenethylamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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