Document Detail


Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial.
MedLine Citation:
PMID:  11747380     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Initial findings from the Dietary Approaches to Stop Hypertension (DASH)-Sodium Trial demonstrated that reduction of sodium intake in two different diets decreased blood pressure in participants with and without hypertension. OBJECTIVE: To determine effects on blood pressure of reduced sodium intake and the DASH diet in additional subgroups. DESIGN: Randomized feeding study. SETTING: Four clinical centers and a coordinating center. PARTICIPANTS: 412 adults with untreated systolic blood pressure of 120 to 160 mm Hg and diastolic blood pressure of 80 to 95 mm Hg. INTERVENTION: Participants followed the DASH diet or a control (typical U.S.) diet for three consecutive 30-day feeding periods, during which sodium intake (50, 100, and 150 mmol/d at 2100 kcal) varied according to a randomly assigned sequence. Body weight was maintained. MEASUREMENTS: Systolic and diastolic blood pressure. RESULTS: In all subgroups, the DASH diet and reduced sodium intake were each associated with significant decreases in blood pressure; these two factors combined produced the greatest reductions. Among nonhypertensive participants who received the control diet, lower (vs. higher) sodium intake decreased blood pressure by 7.0/3.8 mm Hg in those older than 45 years of age (P < 0.001) and by 3.7/1.5 mm Hg in those 45 years of age or younger (P < 0.05). CONCLUSION: The DASH diet plus reduced sodium intake is recommended to control blood pressure in diverse subgroups.
Authors:
W M Vollmer; F M Sacks; J Ard; L J Appel; G A Bray; D G Simons-Morton; P R Conlin; L P Svetkey; T P Erlinger; T J Moore; N Karanja;
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  135     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-18     Completed Date:  2002-01-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1019-28     Citation Subset:  AIM; IM    
Affiliation:
Center for Health Research, 3800 North Interstate Avenue, Portland, OR 97227, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Blood Pressure / physiology*
Diet, Sodium-Restricted*
Ethnic Groups
Female
Humans
Hypertension / ethnology,  physiopathology,  prevention & control*
Linear Models
Male
Middle Aged
Regression Analysis
Sex Factors
Grant Support
ID/Acronym/Agency:
HL03857-01/HL/NHLBI NIH HHS; M01-RR00722/RR/NCRR NIH HHS; M01-RR02635/RR/NCRR NIH HHS; U01-HL 57173/HL/NHLBI NIH HHS; U01-HL57114/HL/NHLBI NIH HHS; U01-HL57139/HL/NHLBI NIH HHS; U01-HL57156/HL/NHLBI NIH HHS; U01-HL57190/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Ann Intern Med. 2002 Nov 5;137(9):772-3; author reply 772-3   [PMID:  12416957 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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