Document Detail


Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial.
MedLine Citation:
PMID:  16020749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To explore the separate and combined effects of simvastatin and a low-saturated diet rich in alpha-linolenic acid on serum fatty acids. METHODS AND RESULTS: 120 hypercholesterolemic men were randomly allocated to a habitual diet or dietary treatment group and to receive, in random order, simvastatin 20 mg/d or placebo, each for 12 weeks, in a double-blind manner. Dietary treatment decreased proportions from total fatty acids of palmitic acid (C16:0) by 3.3% (P<0.05), stearic acid (C18:0) by 3.7% (P<0.05) and increased proportions of oleic acid (C18:1n-9) by 4.2% (P<0.01), and alpha-linolenic acid (C18:3n-3) by 29.8% (P<0.001). Simvastatin decreased proportions from total fatty acids of palmitic acid by 2.0% (P<0.01), linoleic acid (C18:2n-6) by 5.3% (P<0.001), and alpha-linolenic acid by 6.8% (P<0.05), and increased proportions of gamma-linolenic acid (C18:3n-6) by 11.1% (P<0.001), dihomo-gamma-linolenic acid (C20:3n-6) by 4.2% (P<0.01), arachidonic acid (C20:4n-6) by 14.2% (P<0.001), and the sum of long-chain polyunsaturated fatty acids (C20-22) by 9.0% (P<0.001). Simvastatin increased ratios of stearic to palmitic, gamma-linolenic to linoleic, and arachidonic to dihomo-gamma-linolenic acid by 7.6%, 17.0%, and 10.0% (P<0.001 for all), respectively, suggesting increased fatty acid elongase and Delta6- and Delta5-desaturase enzyme activities. CONCLUSIONS: Increased formation of long-chain polyunsaturated fatty acids and their metabolites may contribute a substantial part of the pleiotropic effects of simvastatin.
Authors:
Antti Jula; Jukka Marniemi; Tapani Rönnemaa; Arja Virtanen; Risto Huupponen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2005-07-14
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  25     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-29     Completed Date:  2006-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1952-9     Citation Subset:  IM    
Affiliation:
Department of Health and Functional Capacity, National Public Health Institute of Finland, Turku, Finland. antti.jula@ktl.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticholesteremic Agents / administration & dosage*
Combined Modality Therapy
Dietary Fats / administration & dosage,  blood
Fatty Acids / blood
Fatty Acids, Unsaturated / blood
Food Habits
Humans
Hypercholesterolemia / diet therapy*,  drug therapy*
Male
Middle Aged
Simvastatin / administration & dosage*
Treatment Outcome
alpha-Linolenic Acid / administration & dosage*,  blood
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 463-40-1/alpha-Linolenic Acid; 79902-63-9/Simvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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