| Effects of diet and simvastatin on fatty acid composition in hypercholesterolemic men: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 16020749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To explore the separate and combined effects of simvastatin and a low-saturated diet rich in alpha-linolenic acid on serum fatty acids. METHODS AND RESULTS: 120 hypercholesterolemic men were randomly allocated to a habitual diet or dietary treatment group and to receive, in random order, simvastatin 20 mg/d or placebo, each for 12 weeks, in a double-blind manner. Dietary treatment decreased proportions from total fatty acids of palmitic acid (C16:0) by 3.3% (P<0.05), stearic acid (C18:0) by 3.7% (P<0.05) and increased proportions of oleic acid (C18:1n-9) by 4.2% (P<0.01), and alpha-linolenic acid (C18:3n-3) by 29.8% (P<0.001). Simvastatin decreased proportions from total fatty acids of palmitic acid by 2.0% (P<0.01), linoleic acid (C18:2n-6) by 5.3% (P<0.001), and alpha-linolenic acid by 6.8% (P<0.05), and increased proportions of gamma-linolenic acid (C18:3n-6) by 11.1% (P<0.001), dihomo-gamma-linolenic acid (C20:3n-6) by 4.2% (P<0.01), arachidonic acid (C20:4n-6) by 14.2% (P<0.001), and the sum of long-chain polyunsaturated fatty acids (C20-22) by 9.0% (P<0.001). Simvastatin increased ratios of stearic to palmitic, gamma-linolenic to linoleic, and arachidonic to dihomo-gamma-linolenic acid by 7.6%, 17.0%, and 10.0% (P<0.001 for all), respectively, suggesting increased fatty acid elongase and Delta6- and Delta5-desaturase enzyme activities. CONCLUSIONS: Increased formation of long-chain polyunsaturated fatty acids and their metabolites may contribute a substantial part of the pleiotropic effects of simvastatin. |
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Authors:
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Antti Jula; Jukka Marniemi; Tapani Rönnemaa; Arja Virtanen; Risto Huupponen |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2005-07-14 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 25 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-29 Completed Date: 2006-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1952-9 Citation Subset: IM |
Affiliation:
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Department of Health and Functional Capacity, National Public Health Institute of Finland, Turku, Finland. antti.jula@ktl.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticholesteremic Agents / administration & dosage* Combined Modality Therapy Dietary Fats / administration & dosage, blood Fatty Acids / blood Fatty Acids, Unsaturated / blood Food Habits Humans Hypercholesterolemia / diet therapy*, drug therapy* Male Middle Aged Simvastatin / administration & dosage* Treatment Outcome alpha-Linolenic Acid / administration & dosage*, blood |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Unsaturated; 463-40-1/alpha-Linolenic Acid; 79902-63-9/Simvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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