Document Detail

Effects of diet and behavioral enrichment on free fatty acids in the aged canine brain.
MedLine Citation:
PMID:  22183056     Owner:  NLM     Status:  MEDLINE    
Despite several recent studies suggesting that dysregulation of brain lipid metabolism might contribute to the mechanisms of aging and Alzheimer's disease (AD), lipid metabolism has not been evaluated extensively in the aging brain. Here, we use a lipidomic approach to demonstrate that antioxidants plus mitochondrial cofactors treatment, either alone or in combination with behavioral enrichment, attenuates lipid abnormalities in the frontal cortices of aged canine in a manner correlated with cognitive scores. Our analyses revealed that the levels of free palmitoleic acid and nervonic acid were decreased in frontal cortices of aged dogs (n=5-6/group) treated with antioxidant compared with the control group. The monounsaturated/saturated fatty acid ratio, also known as "desaturation index"-an ex-vivo indicator of stearoyl-CoA desaturase activity, was also reduced in the frontal cortex of dogs treated with antioxidants compared with control groups. Increased palmitoleic acid levels and desaturation index were positively correlated with increased reversal learning errors and decreased cognitive performance. In conclusion, our study indicates that the addition of antioxidants and mitochondrial cofactors to the regular diet alters the composition of free fatty acids in the aged brain. Together with data showing increased palmitoleic acid levels in AD patients, our data suggest that reducing palmitoleic acid levels and desaturation index in the brain may be associated with improved cognitive performance.
S Snigdha; G Astarita; D Piomelli; C W Cotman
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Publication Detail:
Type:  Journal Article     Date:  2011-12-13
Journal Detail:
Title:  Neuroscience     Volume:  202     ISSN:  1873-7544     ISO Abbreviation:  Neuroscience     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-05-18     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  7605074     Medline TA:  Neuroscience     Country:  United States    
Other Details:
Languages:  eng     Pagination:  326-33     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Ltd.
Institute for Memory Impairments and Neurological Disorders, University of California Irvine, Irvine, CA, USA.
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MeSH Terms
Aging / metabolism*
Alzheimer Disease / metabolism
Arachidonic Acid / metabolism
Behavior, Animal / physiology*
Brain Chemistry / physiology*
Cognition / physiology
Discrimination (Psychology) / physiology
Discrimination Learning / physiology
Fatty Acids, Monounsaturated / metabolism
Fatty Acids, Nonesterified / metabolism*
Lipid Metabolism / physiology
Physical Conditioning, Animal / physiology
Reversal Learning / physiology
Social Environment
Stearoyl-CoA Desaturase / metabolism
Grant Support
Reg. No./Substance:
0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Nonesterified; 209B6YPZ4I/palmitoleic acid; 506-32-1/Arachidonic Acid; 506-37-6/nervonic acid; EC Desaturase

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