| Effects of the diazafluoranthen derivative AC-3579 (NSC-170561), a new experimental antitumour drug, on rat hepatoma. | |
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MedLine Citation:
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PMID: 174050 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of AC-3579 (NSC-170561), a new experimental antitumour drug which depresses phospholipid catabolism in liver, were compared in rat aflatoxin-induced hepatoma and in non-neoplastic hepatocytes surrounding the tumour. Ultrastructural lesions, characterized by the hypertrophy of the smooth endoplasmic reticulum and the presence of lamellate cytosomes appeared in both tissues. They were less marked in hepatoma than in non-neoplastic cells. As in control livers, they were related to an invrease in pohspholipid concentration due to the decrease of phospholipid breakdown. In addition, chemical analysis demonstrated differences between hepatoma, non-neoplastic aflatoxin-treated liver and control liver: total and free cholesterol were decreased, relative concentration of sphingomyelin increased and that of phosphatidylethanolamine decreased by about 50%, in both hepatoma and non-neoplastic liver. Phospholipid concentration was decreased by 50% in tumour cells. After AC-3579 treatment total cholesterol was increased 3.2 fold in non-neoplastic liver and 2.5 fold in hepatoma but not in control liver. |
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Authors:
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O Thys; J Hildebrand; Y Gerin |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Pathologia Europaea Volume: 10 ISSN: 0031-2967 ISO Abbreviation: Pathol Eur Publication Date: 1975 |
Date Detail:
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Created Date: 1976-04-01 Completed Date: 1976-04-01 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0062702 Medline TA: Pathol Eur Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 251-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aflatoxins Animals Antineoplastic Agents / pharmacology, therapeutic use* Aza Compounds / pharmacology, therapeutic use* Carcinoma, Hepatocellular / chemically induced, drug therapy*, metabolism, pathology Endoplasmic Reticulum / drug effects Fluorenes / pharmacology, therapeutic use* Liver / drug effects, metabolism, ultrastructure Liver Neoplasms / chemically induced, drug therapy*, metabolism, pathology Male Neoplasms, Experimental / chemically induced, drug therapy, metabolism, pathology Phosphates / metabolism Rats |
| Chemical | |
Reg. No./Substance:
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0/Aflatoxins; 0/Antineoplastic Agents; 0/Aza Compounds; 0/Fluorenes; 0/Phosphates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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