Document Detail


Effects of diaspirin crosslinked hemoglobin infusion in treadmill-exercised swine.
MedLine Citation:
PMID:  10543308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hemodynamic and metabolic effects of diaspirin crosslinked hemoglobin (DCLHb) were investigated using graded treadmill exercise in swine (n = 5/group). Swine received DCLHb (10% solution, 5 ml/kg) or oncotically-matched human serum albumin (HSA, 5ml/kg). Baseline metabolic and hemodynamic data were similar. In both groups exercise increased hemodynamic parameters. Exercise increased heart rate (HR) from 139 +/- 12 to 293 +/- 28 bpm with DCLHb and from 136 +/- 13 to 314 +/- 13 bpm with HSA. Exercise increased cardiac output (CO) from 5.7 +/- 0.75 to 15.6 +/- 2.01/min in the DCLHb group and from 5.3 +/- 0.48 to 15.7 +/- 0.881/min in the HSA group. However, CO returned to baseline faster with DCLHb upon stopping exercise. The DCLHb-treated group demonstrated a significantly higher oxygen extraction during exercise (12.04 +/- 0.38 vs 9.48 +/- 0.99 ml O2/100 ml blood) and a lower oxygen delivery throughout recovery (74.6 +/- 6.6 vs 102.2 +/- 7.21 O2/min), indicating enhanced oxygen delivery during exercise in the treatment group. DCLHb infusion did not impair metabolic or hemodynamic functions. These data indicate that DCLHb may increase oxygen delivery to working tissue more efficiently than HSA during treadmill exercise in swine.
Authors:
M S Crago; S D West; J E McKenzie
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Heart and vessels     Volume:  14     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1999  
Date Detail:
Created Date:  1999-12-02     Completed Date:  1999-12-02     Revised Date:  2010-01-20    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspirin / administration & dosage,  analogs & derivatives*,  pharmacology
Blood Gas Analysis
Blood Substitutes / administration & dosage,  pharmacology*
Energy Metabolism / drug effects*
Exercise Test
Female
Hemodynamics / drug effects*
Hemoglobins / administration & dosage,  pharmacology*
Hydrogen-Ion Concentration
Infusions, Intravenous
Male
Oxygen Consumption / drug effects
Physical Conditioning, Animal*
Swine / physiology*
Chemical
Reg. No./Substance:
0/Blood Substitutes; 0/Hemoglobins; 0/diaspirin-cross-linked hemoglobin; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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