Document Detail

Effects of diabetes mellitus on cholesterol metabolism in man.
MedLine Citation:
PMID:  870827     Owner:  NLM     Status:  MEDLINE    
In view of the reported excess prevalence of atherosclerosis and cholelithiasis in diabetes, we investigated several aspects of cholesterol metabolism under metabolic ward conditions in six Pima Indians with maturity-onset diabetes mellitus. Cholesterol balance (13.5 versus 11.0 mg per kilogram per day, P less than 0.05), fecal bile acid excretion (415 versus 261 mg per day, P less than 0.05), bile acid pool size (3150 versus 1950 mg, P less than 0.05), fasting plasma cholesterol (193 versus 160 mg per deciliter, P less than 0.05) and plasma triglycerides (251 versus 150 mg per deciliter, P less than 0.05) were higher during uncontrolled hyperglycemia than during relative euglycemia on insulin. The increased plasma lipid levels and total cholesterol synthesis during hyperglycemia may contribute to the acceleration of atherosclerosis in diabetes mellitus. Gallbladder bile was significantly more saturated with cholesterol (181 per cent versus 114 per cent, P less than 0.05) during insulin treatment than during uncontrolled hyperglycemia. Bile lipid composition was thus more favorable to cholesterol precipitation and gallstone formation during insulin treatment than in the untreated diabetic state.
L J Bennion; S M Grundy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The New England journal of medicine     Volume:  296     ISSN:  0028-4793     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1365-71     Citation Subset:  AIM; IM    
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MeSH Terms
Arteriosclerosis / etiology
Bile / metabolism
Bile Acids and Salts / metabolism
Blood Glucose / analysis
Cholesterol / blood,  metabolism*
Diabetes Mellitus / blood,  drug therapy,  metabolism*
Insulin / pharmacology,  therapeutic use
Lipid Metabolism
Lipids / blood
Lipoproteins / blood
Middle Aged
Triglycerides / blood
Reg. No./Substance:
0/Bile Acids and Salts; 0/Blood Glucose; 0/Lipids; 0/Lipoproteins; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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