| Effects of dextran 70 versus crystalloids in the microcirculation of porcine hemorrhagic pancreatitis. | |
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MedLine Citation:
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PMID: 2424105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cause of hemodynamic changes occurring during acute pancreatitis remains obscure. Using a pig model of acute hemorrhagic pancreatitis and the reference sample method with 113Tin and 46 Scandium labelled microspheres, blood flow to organs was determined before and five hours after the induction of pancreatitis. Blood pressure, pulse rate and cardiac output were measured hourly. There were two treatment groups. The first group received dextran 70 (5.7 milliliters per kilogram per hour) and saline solution (7.5 milliliters per kilogram per hour) in sufficient amounts to maintain cardiac output at the initial (prepancreatic) level. The second group received saline solution (26 milliliters per kilogram per hour) only and during the experiment the cardiac output was allowed to decrease to approximately one-half of the initial level. In the dextran 70 group, blood flow in various organs stayed at the initial level or was slightly increased. However, in the saline solution group there was a marked and significant decrease in the blood flow in all organs except the antral mucosa, gallbladder and adrenal glands. The changes in the pancreatic fraction of the cardiac output during the experiment were similar to those of other organs in respective treatment groups. In conclusion, adequate infusion of dextran maintains cardiac output and organ microcirculation at the initial level during the early phase of acute hemorrhagic pancreatitis. It is suggested that the hemodynamic changes which develop during acute pancreatitis are mainly secondary to the ensuing hypovolemia and not direct consequences of the pancreatic inflammatory process. |
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Authors:
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A Lehtola; E Kivilaakso; P Puolakkainen; S L Karonen; M Lempinen; T Schröder |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Surgery, gynecology & obstetrics Volume: 162 ISSN: 0039-6087 ISO Abbreviation: Surg Gynecol Obstet Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-06-30 Completed Date: 1986-06-30 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0101370 Medline TA: Surg Gynecol Obstet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 556-62 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure Cardiac Output Dextrans / therapeutic use* Fluid Therapy* Hemorrhage / physiopathology, therapy* Microcirculation / physiopathology Microspheres Pancreas / blood supply Pancreatic Diseases / physiopathology, therapy Pancreatitis / physiopathology, therapy* Pulse Radioisotopes / diagnostic use Sodium Chloride / therapeutic use Swine |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 7647-14-5/Sodium Chloride; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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