Document Detail

Effects of dextran 70 versus crystalloids in the microcirculation of porcine hemorrhagic pancreatitis.
MedLine Citation:
PMID:  2424105     Owner:  NLM     Status:  MEDLINE    
The cause of hemodynamic changes occurring during acute pancreatitis remains obscure. Using a pig model of acute hemorrhagic pancreatitis and the reference sample method with 113Tin and 46 Scandium labelled microspheres, blood flow to organs was determined before and five hours after the induction of pancreatitis. Blood pressure, pulse rate and cardiac output were measured hourly. There were two treatment groups. The first group received dextran 70 (5.7 milliliters per kilogram per hour) and saline solution (7.5 milliliters per kilogram per hour) in sufficient amounts to maintain cardiac output at the initial (prepancreatic) level. The second group received saline solution (26 milliliters per kilogram per hour) only and during the experiment the cardiac output was allowed to decrease to approximately one-half of the initial level. In the dextran 70 group, blood flow in various organs stayed at the initial level or was slightly increased. However, in the saline solution group there was a marked and significant decrease in the blood flow in all organs except the antral mucosa, gallbladder and adrenal glands. The changes in the pancreatic fraction of the cardiac output during the experiment were similar to those of other organs in respective treatment groups. In conclusion, adequate infusion of dextran maintains cardiac output and organ microcirculation at the initial level during the early phase of acute hemorrhagic pancreatitis. It is suggested that the hemodynamic changes which develop during acute pancreatitis are mainly secondary to the ensuing hypovolemia and not direct consequences of the pancreatic inflammatory process.
A Lehtola; E Kivilaakso; P Puolakkainen; S L Karonen; M Lempinen; T Schröder
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Surgery, gynecology & obstetrics     Volume:  162     ISSN:  0039-6087     ISO Abbreviation:  Surg Gynecol Obstet     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-06-30     Completed Date:  1986-06-30     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101370     Medline TA:  Surg Gynecol Obstet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  556-62     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Dextrans / therapeutic use*
Fluid Therapy*
Hemorrhage / physiopathology,  therapy*
Microcirculation / physiopathology
Pancreas / blood supply
Pancreatic Diseases / physiopathology,  therapy
Pancreatitis / physiopathology,  therapy*
Radioisotopes / diagnostic use
Sodium Chloride / therapeutic use
Reg. No./Substance:
0/Radioisotopes; 7647-14-5/Sodium Chloride; 9004-54-0/Dextrans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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