| Effects of dexamethasone on cerebral perfusion and water diffusion in patients with high-grade glioma. | |
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MedLine Citation:
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PMID: 16484419 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: The mechanisms by which the glucocorticoid dexamethasone produces its therapeutic action in patients with intracranial tumors still remain unclear. The purpose of this study was to investigate whether dexamethasone affects cerebral perfusion and water molecule diffusion by using quantitative dynamic susceptibility contrast perfusion MR imaging (DSC-MR imaging) and diffusion tensor MR imaging (DT-MR imaging). METHODS: Ten consecutive patients with glioblastoma multiforme underwent DSC-MR imaging and DT-MR imaging before and 48-72 hours after dexamethasone treatment (16 mg/day). Cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), and water mean diffusivity (<D>) were measured for enhancing tumor, nonenhancing peritumoral edematous brain, and normal-appearing contralateral white matter before and after steroid therapy. The percentage change in CBF, CBV, MTT, and <D> for the 3 tissue types was calculated for each patient, a mean value obtained for the population, and the statistical significance determined by using a paired-samples Student t test. RESULTS: After dexamethasone treatment, there was no significant change in tumor CBF, CBV, or MTT. Edematous brain CBV and MTT were also unchanged. There was, however, an increase in edematous brain CBF (11.6%; P = .05). <D> was reduced in both enhancing tumor (-5.8%; P = .001) and edematous brain (-6.0%; P < .001). There was no significant change in CBF, CBV, MTT, or <D> for normal-appearing contralateral white matter after treatment. CONCLUSION: These data suggest that dexamethasone does not significantly affect tumor blood flow but may, by reducing peritumoral water content and local tissue pressure, subtly increase perfusion in the edematous brain. |
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Authors:
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M E Bastin; T K Carpenter; P A Armitage; S Sinha; J M Wardlaw; I R Whittle |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: AJNR. American journal of neuroradiology Volume: 27 ISSN: 0195-6108 ISO Abbreviation: AJNR Am J Neuroradiol Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-02-17 Completed Date: 2006-04-13 Revised Date: 2008-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8003708 Medline TA: AJNR Am J Neuroradiol Country: United States |
Other Details:
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Languages: eng Pagination: 402-8 Citation Subset: IM |
Affiliation:
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Department of Medical and Radiological Sciences, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Flow Velocity / drug effects Blood Volume / drug effects Blood-Brain Barrier / drug effects* Brain / blood supply* Brain Edema / diagnosis, drug therapy Brain Neoplasms / blood supply*, drug therapy Contrast Media Dexamethasone / therapeutic use* Diffusion Magnetic Resonance Imaging / methods* Female Gadolinium DTPA / diagnostic use Glioblastoma / blood supply*, drug therapy Humans Image Enhancement / methods* Image Processing, Computer-Assisted / methods* Male Middle Aged Prospective Studies Regional Blood Flow / drug effects Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 50-02-2/Dexamethasone; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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