Document Detail

Effects of development of host immunity on the biodistribution of xenogeneic MHC non-restricted cytotoxic T cells: implications for adoptive cell therapy of cancer.
MedLine Citation:
PMID:  9917497     Owner:  NLM     Status:  MEDLINE    
The human MHC non-restricted cytotoxic T cell line TALL-104 has potent anti-tumor effects in dogs with spontaneous tumors. This study was designed to examine the effects of the development of host immune responses on the baseline organ distribution of TALL-104 cells in healthy dogs. 111In-oxine labeled TALL-104 cells (107 cells/kg) were infused systemically in three dogs, either on day 1, 3, or 5 of a 5-day injection cycle; two dogs received two more injections of the labeled cells at monthly intervals, whereas the third dog received free 111In-oxine, 3 months after the first 5-day infusion. Analysis of blood and plasma cell clearances and imaging studies indicated a progressively faster clearance of the cells from the blood and organs after multiple daily injections as well as at the time of each monthly boost when host immune responses against the xenogeneic cells had developed. These findings have important therapeutic implications for the design of effective TALL-104 cell administration schedules in clinical trials.
A Cesano; J A Wortman; M Pourdehnad; S Visonneau; D Mozley; A Bhatnagar; A Alavi; D Santoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oncology     Volume:  14     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-02-16     Completed Date:  1999-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  233-44     Citation Subset:  IM    
The Wistar Institute, Philadelphia, PA 19104, USA.
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MeSH Terms
Immunotherapy, Adoptive*
Major Histocompatibility Complex / immunology*
T-Lymphocytes, Cytotoxic / immunology*,  transplantation
Transplantation, Heterologous

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