Document Detail

Effects of desflurane on the pig intestinal circulation during hypotension.
MedLine Citation:
PMID:  10593474     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of the present study was to analyze the perfusion pressure dependency for the splanchnic vascular effects of desflurane (DES). METHODS: We measured portal blood flow (QPORT, perivascular ultrasound) and jejunal mucosal perfusion (JMP; laser Doppler) in pentobarbital-anesthetized pigs (n=10). Experimentally, decreases in mean arterial pressure (MAP) were produced by pericardial infusions of dextran. The protocol included sets of measurements at incremental doses of DES (1, 2, 4 and 6%) prior to and during pericardial infusions. RESULTS: Although QPORT and JMP decreased significantly during pericardial infusions, DES, irrespective of dose, did not reduce QPORT until MAP had decreased below 65-70 mm Hg. In higher MAP ranges, vasodilation in pre-portal tissues was powerful enough to maintain QPORT in spite of concurrent decreases in driving arterial pressure, as produced by either DES or pericardial infusion, or by a combination of both. We found no effects of DES on JMP even at very low MAP (about 40 mm Hg during pericardial infusion), indicating that the normal physiological response of the small intestine to redistribute blood flow from deeper to more superficial layers during hypotension was unimpaired by DES. CONCLUSIONS: Our data suggest a wide dose-tolerability of DES as regards the splanchnic circulation during hypotensive states.
H Sundeman; A Aneman; M Broomé; M Haney; G Johansson; S Häggmark; B Biber; O Winsö
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta anaesthesiologica Scandinavica     Volume:  43     ISSN:  0001-5172     ISO Abbreviation:  Acta Anaesthesiol Scand     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-22     Completed Date:  1999-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370270     Medline TA:  Acta Anaesthesiol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1069-77     Citation Subset:  IM    
Department of Anesthesiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
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MeSH Terms
Anesthetics, Inhalation / pharmacology*
Blood Flow Velocity / drug effects
Cardiac Output / drug effects
Dose-Response Relationship, Drug
Heart Rate / drug effects
Hypotension / physiopathology*
Intestinal Mucosa / blood supply
Intestines / blood supply*
Isoflurane / analogs & derivatives*,  pharmacology
Jejunum / blood supply
Laser-Doppler Flowmetry
Oxygen / blood
Portal Pressure / drug effects
Portal Vein / physiology
Stroke Volume / drug effects
Vascular Resistance / drug effects
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane; 57041-67-5/desflurane; 7782-44-7/Oxygen

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