Document Detail


Effects of deprenyl on monoamine oxidase and neurotransmitters in the brains of MPTP-treated aging mice.
MedLine Citation:
PMID:  7544444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Deprenyl is a selective monoamine oxidase B (MAO-B) inhibitor and has been used in the treatment of Parkinson's disease. However, it is not known whether deprenyl effects are symptomatic or pharmacological. Aging mice were partially lesioned with MPTP. Control and MPTP-treated mice were given deprenyl in drinking water for 14 days. Brain tissue (including the striatum, olfactory tubercle and cerebral cortex) was assayed for MAO-B and neurotransmitter levels. The results show that deprenyl treatment, given alone or after MPTP, reduced MAO-B activity in all the three regions. No change was seen in dopamine (DA), 3,4-dihydroxyphenyl acetic acid (DOPAC), and homovanillic acid (HVA) content in any of the three areas. Cortical norepinephrine (NE) levels were also unaltered. However, striatal serotonin (5-HT) levels were decreased while its metabolite, 5-HIAA levels were significantly increased in the olfactory tubercle in animals receiving deprenyl alone. These data suggest that deprenyl treatment reduces MAO-B activity in regions in addition to the striatum without affecting norepinephrine, dopamine (DA) and its metabolites.
Authors:
M Gupta; H L Wiener
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurochemical research     Volume:  20     ISSN:  0364-3190     ISO Abbreviation:  Neurochem. Res.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-09-27     Completed Date:  1995-09-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7613461     Medline TA:  Neurochem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  385-9     Citation Subset:  IM    
Affiliation:
Department of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine, Kentucky 40292, USA.
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
3,4-Dihydroxyphenylacetic Acid / metabolism
Aging / metabolism*
Animals
Brain / drug effects*,  enzymology,  metabolism
Corpus Striatum / drug effects
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Male
Mice
Mice, Inbred C57BL
Monoamine Oxidase / drug effects*
Neurotransmitter Agents / metabolism*
Olfactory Pathways / drug effects
Selegiline / pharmacology*
Grant Support
ID/Acronym/Agency:
NS24291/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 14611-51-9/Selegiline; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; EC 1.4.3.4/Monoamine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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