Document Detail

Effects of deoxyribonucleoside 5'-monophosphates on human skin conditions.
MedLine Citation:
PMID:  20642780     Owner:  NLM     Status:  In-Data-Review    
Vol. 43, No.3 (2009) pp.209-216 We investigated the effects of deoxyribonucleoside 5'-monophosphates (dNMP) on human skin conditions. dNMPs (dAMP, dGMP, dCMP, dTMP) were prepared from salmon milt DNA using enzymatic and chromatographic techniques. First, we investigated the rubbing test of dNMP mixture on skin. 1% of dNMP mixture-containing cream (1%-dNMP group), 3% of dNMP mixture-containing cream (3%-dNMP group), or no dNMP-containing cream (control group) was rubbed on the skin of the face and hand of the male subjects (ten / each group) for 12 weeks. The 1%-dNMP group had significantly improved skin-elasticity compared to that of the control group at 8 weeks, and the tendency of improvement of skin-elasticity was also recognized at 4 and 12 weeks. The 3%-dNMP group tended to have improved skin-elasticity at every period. The water content of face skin was significantly increased in the 3%-dNMP group at 12 weeks. In addition, in the questionnaire, more than 80% of the 3%-dNMP group answered that they felt the improvement of skin roughness after 4 weeks. These results indicated that the dNMP mixture has the effect of improving skin conditions by rubbing. Next, we evaluated the effect of the enzymatic digested DNA-Na which contained dNMPs using normal dermal fibroblast from human skin (SF-TY cell). Enzymatic digested DNA-Na showed the activation effect of cell proliferation and the promoting effect of collagen production on SF-TY cell. In a comparison of dNMPs, dAMP showed the highest activity of collagen production.
T-F Hsu; M-F Wang; S Yamamoto; H Sekido; Y Hoshino; A Honmura; R Akita; H Enari
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cosmetic science     Volume:  32     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  317     Citation Subset:  IM    
Department of Applied Cosmetology and Graduate Institute of Cosmetic Science, Hungkung University, No.34, Chung-Chie Rd., Shalu, Taichung County 43302, Taiwan;
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