Document Detail

Effects of deoxynivalenol and zearalenone on oxidative stress and blood phagocytic activity in broilers.
MedLine Citation:
PMID:  18763624     Owner:  NLM     Status:  MEDLINE    
Effects of dietary contamination with various levels of deoxynivalenol (DON) and zearalenone (ZEA) were investigated on Ross 308 hybrid broilers of both sexes. After hatching, all chickens were fed an identical control diet for two weeks. Then chickens of Group 1 received a diet contaminated with DON and ZEA, both being 3.4 mg kg(-1), while Group 2 received DON and ZEA at 8.2 and 8.3 mg kg(-1), respectively. The diet of the control group contained background levels of mycotoxins. Samples of blood and tissues were collected after two weeks. Intake of both contaminated diets resulted in a significantly decreased activity of glutathione peroxidase (GPx) and increased level of malondialdehyde (MDA) in liver tissue, while in kidneys the concentration of MDA was significantly increased only in Group 1. On the other hand, activities of blood GPx and plasma gamma-glutamyltransferase (GGT) were elevated in Group 2 only. Activities of thioredoxin reductase in liver and GPx in duodenal mucosa tissues, superoxide dismutase (SOD) in erythrocytes as well as levels of MDA in duodenal mucosa and alpha-tocopherol in plasma were not affected by dietary mycotoxins. Blood phagocytic activity was significantly depressed in Group 1 and 2. These results demonstrate that diets contaminated with DON and ZEA at medium levels are already able to induce oxidative stress and compromise the blood phagocytic activity in fattening chickens.
Radka Borutova; Stefan Faix; Iveta Placha; Lubomira Gresakova; Klaudia Cobanova; Lubomir Leng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of animal nutrition     Volume:  62     ISSN:  1745-039X     ISO Abbreviation:  -     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-09-03     Completed Date:  2008-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101222433     Medline TA:  Arch Anim Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  303-12     Citation Subset:  IM    
Institute of Animal Physiology, Slovak Academy of Sciences, Kosice, Slovak Republic.
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MeSH Terms
Animal Feed
Animals, Newborn
Chickens / growth & development,  immunology,  metabolism*
Dose-Response Relationship, Drug
Food Contamination*
Fusarium / metabolism
Glutathione Peroxidase / metabolism
Kidney / metabolism
Lipid Peroxidation / drug effects
Liver / enzymology,  metabolism
Malondialdehyde / metabolism
Oxidative Stress / drug effects*,  immunology,  physiology
Phagocytosis / drug effects*,  immunology,  physiology
Random Allocation
Trichothecenes / toxicity*
Zea mays / chemistry
Zearalenone / toxicity*
Reg. No./Substance:
0/Trichothecenes; 17924-92-4/Zearalenone; 51481-10-8/deoxynivalenol; 542-78-9/Malondialdehyde; EC Peroxidase

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